Results 81 to 90 of about 1,087 (186)
Peptides in BioNMR Research [PDF]
, 2021 Heteronuclear NMR in combination with isotope labelling is used to study folding of polypeptides induced by metals in the case of metallothioneins, binding of the peptidic allosteric modulator ?-TIA to the human G-protein coupled ?1b adrenergic receptor,
Baumann, Christian +5 more
core +2 more sources
α-Conopeptides specifically expressed in the salivary gland of Conus pulicarius [PDF]
Toxicon, 2008 To date, studies conducted on cone snail venoms have attributed the origins of this complex mixture of neuroactive peptides entirely to gene expression by the secretory cells lining the lumen of the venom duct. However, specialized tissues such as the salivary glands also secrete their contents into the anterior gut and could potentially contribute ...
Jason S, Biggs +2 more
openaire +2 more sources
Analgesic treatment of ciguatoxin-induced cold allodynia [PDF]
, 2013 Ciguatera, the most common form of nonbacterial ichthyosarcotoxism, is caused by consumption of fish that have bioaccumulated the polyether sodium channel activator ciguatoxin.
Cabot, Peter J. +8 more
core +1 more source
New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels
Marine Drugs, 2006 Selective blockers of the N-type voltage-sensitive calcium (CaV) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type CaV channel blocker, SO-3, are reviewed.
Lei Wen +4 more
doaj +1 more source
Identification and Characterization of a Novel Family of Cysteine-Rich Peptides (MgCRP-I) from Mytilus galloprovincialis [PDF]
, 2015 We report the identification of a novel gene family (named MgCRP-I) encoding short secreted cysteine-rich peptides in the Mediterranean mussel Mytilus galloprovincialis.
Benincasa, Monica +12 more
core +2 more sources
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George +12 more
wiley +1 more source
Snails In Silico: A Review of Computational Studies on the Conopeptides. [PDF]
Mar Drugs, 2019 Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides both as a defense mechanism and as a means to immobilize and kill their prey. These peptide toxins exhibit a large chemical diversity that enables exquisite specificity and potency for target receptor proteins.
Mansbach RA +4 more
europepmc +5 more sources
Pharmacological Inhibition of Voltage-gated Ca2+ Channels for Chronic Pain Relief [PDF]
, 2014 Chronic pain is a major therapeutic problem as the current treatment options are unsatisfactory with low efficacy and deleterious side effects. Voltage-gated Ca2+ channels (VGCCs), which are multi-complex proteins consisting of α1, β, γ, and α2δ subunits,
Lee, Seungkyu
core +1 more source
Stabilization of a-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization [PDF]
, 2011 a-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including
Adams, DJ +8 more
core
Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa
Marine Drugs, 2019 The piscivorous cone snail Conus tulipa has evolved a net-hunting strategy, akin to the deadly Conus geographus, and is considered the second most dangerous cone snail to humans. Here, we present the first venomics study of C.
Mriga Dutt +5 more
doaj +1 more source