Results 81 to 90 of about 771 (173)
Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor
, 2013 The G protein-coupled receptor (GPCR) superfamily is an important drug target that includes over 1000 membrane receptors that functionally couple extracellular stimuli to intracellular effectors.
Lewis, Richard J. +7 more
core +1 more source
, 2016 Conopeptide gene superfamilies that were reclassified and provided new names in this study.
Michael Alfaro (762174) +2 more
core +1 more source
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity [PDF]
, 2013 Marine cone snails have developed sophisticated chemical strategies to capture prey and defend themselves against predators. Among the vast array of bioactive molecules in their venom, peptide components called conotoxins or conopeptides dominate, with ...
Lewis, Richard J. +8 more
core +1 more source
Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain
Therapeutics and Clinical Risk Management, 2009 Howard S Smith,1 Timothy R Deer21Albany Medical College, Department of Anesthesiology, Albany, New York, USA; 2The Center for Pain Relief, Clinical Professor, West Virginia, University, Charleston, West Virginia, USAAbstract: Ziconotide is a conopeptide ...
Howard S Smith, Timothy R Deer
doaj
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain
, 2005 Xen2174 is a structural analogue of Mr1A, a χ-conopeptide recently isolated from the venom of the marine cone snail, Conus marmoreus. Although both χ-conopeptides are highly selective inhibitors of the norepinephrine transporter (NET), Xen2174 has ...
Lewis, Richard J. +8 more
core +1 more source
, 2009 Peptides from venom of marine cone snails are regarded as promising novel ligands in drug discovery race. They are highly specific, up to subtype level, leading to new therapeutic insights for clinical and neuropharmacological research and applications ...
Ramasamy, Saminathan
core
, 2015 The venom of each species of Conus contains different kinds of pharmacologically active peptides which are mostly unique to that species. Collectively, the similar to 500-700 species of Conus produce a large number of these peptides, perhaps exceeding ...
Barghi, N. ; https://orcid.org/ +3 more
core +1 more source
conoGenetix biosciences – „Alte“ Naturstoffe und modernes Drug Design
, 2004 Zusammenfassung Ozeane bedecken zwei Drittel der Erdoberfläche und bilden damit das größte und sicherlich wertvollste Ökosystem der Erde.
Andreas Klostermann
core +1 more source
, 2012 International audienceAlthough cone snail venoms have been intensively investigated in the past few decades, little is known about the whole conopeptide and protein content in venom ducts, especially at the transcriptomic level.
David Piquemal +15 more
core +1 more source
, 2016 Conotoxin composition overlap values (D). Values calculated by (a) the frequency of conopeptide membership to different gene superfamilies (b) the percent expression level of each gene superfamily.
Michael Alfaro (762174) +2 more
core +1 more source