A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8 [PDF]
Biochemical Journal, 2007 Vasopressins and oxytocins are homologous, ubiquitous and multifunctional peptides present in animals. Conopressins are vasopressin/oxytocin-related peptides that have been found in the venom of cone snails, a genus of marine predatory molluscs that envenom their prey with a complex mixture of neuroactive peptides.
Carolina, Möller, Frank, Marí
openaire +2 more sources
Conotoxins: structure, therapeutic potential and pharmacological applications. [PDF]
, 2016 Cone snails, also known as marine gastropods, from Conus genus produce in their venom a diverse range of small pharmacologically active structured peptides called conotoxins.
Kamal, M. +9 more
core +2 more sources
Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic [PDF]
, 2015 The design of disulfide bond mimetics is an important strategy for optimising cysteine-rich peptides in drug development. Mimetics of the drug lead conotoxin MrIA, in which one disulfide bond is selectively replaced of by a 1,4-disubstituted-1,2,3 ...
Alewood, Paul F. +10 more
core +2 more sources
[Role of P/Q calcium channel in familial hemiplegic migraine] [PDF]
, 2007 International audienceVoltage-dependent calcium channels constitute one of the main pathways of calcium entry into neurons. They are the principal actors of synaptic transmission by controlling the release of neurotransmitters.
de Waard, Michel +2 more
core +2 more sources
A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity. [PDF]
, 2018 We here describe a novel α-conopeptide, Eu1.6 from Conus eburneus, which exhibits strong anti-nociceptive activity by an unexpected mechanism of action.
Adams, David +14 more
core +3 more sources
Venomics as a Drug Discovery Platform: Identifying Conopeptides with Pharmacological Activity [PDF]
, 2020 Cone snail venom is a mixture of disulfide-constrained peptides (conotoxins), hormone-like peptides, and proteins that have been ‘weaponized’ for predation and defense.
Grandal, Meghan Kathleen
core +1 more source
Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain
Therapeutics and Clinical Risk Management, 2009 Howard S Smith,1 Timothy R Deer21Albany Medical College, Department of Anesthesiology, Albany, New York, USA; 2The Center for Pain Relief, Clinical Professor, West Virginia, University, Charleston, West Virginia, USAAbstract: Ziconotide is a conopeptide ...
Howard S Smith, Timothy R Deer
doaj
The Use of Neurotoxins for Palliative Treatment of Chronic Joint Pain [PDF]
, 2019 Osteoarthritis is a significant public health problem and is rapidly increasing in prevalence with the aging population. Pain is the most disabling consequence of osteoarthritis.
Krug, Hollis
core +2 more sources
Conus peptides: phylogenetic range of biological activity [PDF]
, 1992 Journal ArticleThe major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less ...
Cruz, Lourdes J., Olivera, Baldomero M.
core
Konopeptiidide klassifitseermine ja kindlakstegemine varjatud Markovi mudelite ja positsioonispetsiifiliste skoorimaatriksite abil [PDF]
, 2015 Väitekirja elektrooniline versioon ei sisalda publikatsioone.Konopeptiidid on soojades meredes elavate koonustigude (Conus sp.) mürgis leiduvad lühikesed valgud. Koonusteod on kiskjad ja toituvad ussikestest, teistest molluskitest või kaladest.
Laht, Silja
core