Results 41 to 50 of about 21,330 (214)
Conotoxins that Confer Therapeutic Possibilities [PDF]
Marine Drugs, 2012 Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and ...
Magbubah Essack +2 more
openaire +4 more sources
Toxins, 2015 The α9α10-nicotinic acetylcholine receptor (nAChR) has been implicated in pain and has been proposed to be a novel target for analgesics. However, the evidence to support the involvement of the α9α10-nAChR in pain is conflicted.
Sarasa A. Mohammadi +1 more
doaj +1 more source
Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels
Marine Drugs, 2023 Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
doaj +1 more source
Postsynaptic block of frog neuromuscular transmission by conotoxin GI
, 1985 Conotoxin GI, a peptide neurotoxin contained in the venom of the marine snail Conus geographus, was applied to the cutaneous pectoris muscle of the frog, and the effects on the postsynaptic response to acetylcholine were examined. Conotoxin GI reversibly
JR Musick, OB McManus
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Marine Drugs, 2023 Conotoxins are a class of disulfide-rich peptides found in the venom of cone snails, which have attracted considerable attention in recent years due to their potent activity on ion channels and potential for therapeutics.
Yong Wu +6 more
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British Journal of Pharmacology, EarlyView.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Solution structure of α-conotoxin SI
, 2000 The nuclear magnetic resonance solution structure of α-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that α-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds ...
Hargittai, Balazs +9 more
core +1 more source
The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII [PDF]
, 2001 The alpha-conotoxin MII is a 16 amino acid long peptide toxin isolated from the marine snail, Conus magus. This toxin has been found to be a highly selective and potent inhibitor of neuronal nicotinic acetylcholine receptors of the subtype alpha3beta2 ...
David Craik +15 more
core +1 more source
Biomedicines, 2020 Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits.
Walden E. Bjørn-Yoshimoto +6 more
doaj +1 more source
Preparation and Functional Identification of a Novel Conotoxin QcMNCL-XIII0.1 from Conus quercinus
Toxins, 2022 Conotoxins are tools used by marine Conus snails to hunt and are a significant repository for marine drug research. Conotoxins highly selectively coordinate different subtypes of various ion channels, and a few have been used in pain management. Although
Han Zhang, Anwen Liang, Xinghua Pan
doaj +1 more source