Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. [PDF]
PLoS Computational Biology, 2011 α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission.
Rilei Yu, David J Craik, Quentin Kaas
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The O-carbamoyl-transferase albis is responsible for the modification of albicidin [PDF]
, 2016 Albicidin is a potent antibiotic and phytotoxin produced by the sugarcane pathogenic bacterium Xanthomonas albilineans which targets the plant and bacterial DNA gyrase.[1] The infection occurs through the xylem vessels of the plants where the pathogen ...
Arasté, Julie +10 more
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A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]
, 2005 The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo +59 more
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ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels
Marine Drugs, 2012 The neuronal voltage-gated N-type calcium channel (Cav2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived ω-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared and ...
Peter J. Duggan +7 more
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Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite ...
Gerwig, G.J. +4 more
openaire +5 more sources
Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
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Conotoxin protein classification using free scores of words and support vector machines
BMC Bioinformatics, 2011 Background Conotoxin has been proven to be effective in drug design and could be used to treat various disorders such as schizophrenia, neuromuscular disorders and chronic pain.
Nuel Gregory +3 more
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Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice [PDF]
, 2014 Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also ...
Colettis, Natalia Claudia +8 more
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Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]
, 2017 Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos +11 more
core +3 more sources
Marine Drugs, 2023 Chronic pain is one of the most prevalent health problems worldwide. An alternative to suppress or alleviate chronic pain is the use of peptide drugs that block N-type Ca2+ channels (Cav2.2), such as ω-conotoxin MVIIA.
Xiufang Ding +9 more
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