Results 51 to 60 of about 24,889 (220)

Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]

, 2017
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván, Cano, Raquel, Groisman, Ayelén Ivana, Mazzone, Graciela Luján, Tabares, Lucía, Uchitel, Osvaldo Daniel   +5 more
core   +1 more source

Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails

Marine Drugs, 2023
α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiological or
Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sébastien Dutertre   +8 more
doaj   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Agh R, Arai K, Baskakov IV, Creighton TE, Dittmer K, Du Vigneaud V, Janeček J, Metanis N, Musiol HJ, Muttenthaler M, Nygard B, O'Donnell ME, Welch M, Yang F   +13 more
core   +1 more source

Analysis of a potential new model for neurovascular coupling in retina and its relation to the retinal relaxing factor [PDF]

, 2008
C
Maenhaut, Nele, Van de Voorde, Johan
core   +3 more sources

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]

, 2015
Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Martin, Kelsey C, Vashisht, Ajay, Wohlschlegel, James A   +5 more
core   +1 more source

The T-superfamily of Conotoxins [PDF]

Journal of Biological Chemistry, 1999
Nous rapportons la découverte et la caractérisation initiale de la super-famille T des conotoxines. Huit peptides différents de la superfamille T de cinq espèces de Conus ont été identifiés ; ils partagent une séquence de signal consensuelle et un arrangement conservé de résidus de cystéine (- -CC- -CC-).
Colin Walker, Douglas J. Steel, Richard B. Jacobsen, Marcelina B. Lirazan, Lourdes J. Cruz, David K. Hooper, Reshma Shetty, Richard C. DelaCruz, Jimmi Nielsen, Li Zhou, Pradip K. Bandyopadhyay, A. Grey Craig, Baldomero M. Olivera   +12 more
openaire   +2 more sources

Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications

Journal of Genetic Engineering and Biotechnology
Background: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush, Maged Fouda, Hamdy Aly, Islam Saber, Barakat M. Alrashdi, Diaa Massoud, Sarah Alzwain, Ahmed E. Altyar, Mohamed M. Abdel-Daim, Moustafa Sarhan   +9 more
doaj   +1 more source

Conotoxins that Confer Therapeutic Possibilities [PDF]

Marine Drugs, 2012
Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and ...
Magbubah Essack, Vladimir B. Bajic, John A. C. Archer   +2 more
openaire   +4 more sources

Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization [PDF]

, 2011
alpha-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans ...
Anton A. Grishin, Charlotta Alvarmo, David J. Adams, David J. Craik, Dwoskin LP, Erica S. Lovelace, Norelle L. Daly, Richard J. Clark, Simon T. Nevin, Sunithi Gunasekera, Wüthrich K   +10 more
core   +1 more source

α-Conotoxins

The International Journal of Biochemistry & Cell Biology, 2000
Fil: Blanton, Michael P.
Arias, Hugo Rubén, Blanton, Michael P
openaire   +2 more sources