Results 71 to 80 of about 21,330 (214)

Solution Conformation of αA-conotoxin EIVA, a Potent Neuromuscular Nicotinic Acetylcholine Receptor Antagonist fromConus ermineus

open access: yes, 2003
We report the solution three-dimensional structure of an αA-conotoxin EIVA determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
Baldomero M. Olivera   +10 more
core   +1 more source

α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t

open access: yesToxins, 2017
Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD) spectroscopy and mass spectrometry (MS) were used to assess the effect of each chemical ...
Matthew W. Turner   +2 more
doaj   +1 more source

Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes

open access: yesMarine Drugs, 2019
The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li   +6 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

open access: yesAdvanced Science, Volume 13, Issue 18, 27 March 2026.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian   +5 more
wiley   +1 more source

Inhibition of Escherichia coli chemotaxis by omega-conotoxin, a calcium ion channel blocker

open access: yes, 1993
Escherichia coli chemotaxis was inhibited by omega-conotoxin, a calcium ion channel blocker. With Tris-EDTA-permeabilized cells, nanomolar levels of omega-conotoxin inhibited chemotaxis without loss of motility.
Tisa, Louis S.   +2 more
core   +1 more source

Conopeptides from Cape Verde Conus crotchii

open access: yesMarine Drugs, 2013
Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture.
Agostinho Antunes   +4 more
doaj   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

open access: yesPlant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source

The Potential Role of Calcium Channels in Pulmonary Hypertension

open access: yesBioMed Research International, Volume 2026, Issue 1, 2026.
Pulmonary hypertension (PH) is a severe cardiovascular syndrome characterized by progressively elevated pulmonary arterial pressure and driven pathologically by sustained vasoconstriction and irreversible vascular remodeling. Growing evidence underscores the central role of calcium ion (Ca2+) signaling networks in PH pathogenesis, which dynamically ...
Ping Wu   +5 more
wiley   +1 more source

Synthesis and characterization of μ‐conotoxin IIIa

open access: yes, 1989
μ‐Conotoxin IIIa, a voltage‐dependent sodium channel neurotoxin, has been synthesised using solid‐phase peptide synthesis employing 9‐fluorenylmethoxycarbonyl chemistry.
Becker, S., Gordon, R., Atherton, E.
core   +1 more source

Metabotropic Glutamate Receptor–Dependent Synaptic Plasticity in Age‐Related Neurodegenerative Disorders

open access: yesNeural Plasticity, Volume 2026, Issue 1, 2026.
Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha   +7 more
wiley   +1 more source

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