Results 81 to 90 of about 22,310 (212)

Discovery and characterization of the short κA-conotoxins: A novel subfamily of excitatory conotoxins [PDF]

Toxicon, 2007
We have characterized the defining members of a novel subfamily of excitatory conotoxins, the short kappaA-conotoxins (kappaA(S)-conotoxins). kappaA-conotoxins PIVE and PIVF (kappaA-PIVE and kappaA-PIVF) were purified from Conus purpurascens venom. Both peptides elicited excitatory activity upon injection into fish.
Russell W, Teichert, Richard, Jacobsen, Heinrich, Terlau, Doju, Yoshikami, Baldomero M, Olivera   +4 more
openaire   +2 more sources

The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

Marine Drugs, 2017
The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world.
Samuel D. Robinson, Qing Li, Aiping Lu, Pradip K. Bandyopadhyay, Mark Yandell, Baldomero M. Olivera, Helena Safavi-Hemami   +6 more
doaj   +1 more source

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, Volume 604, Issue 7, Page 3094-3113, 1 April 2026.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

Effects of ω‐conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusor

, 1993
The effects of ω‐conotoxin GVIA (an inhibitor of N‐type voltage‐operated calcium channels; VOCCs) were compared on adrenergic, cholinergic and non‐adrenergic, non‐cholinergic (NANC) responses induced by electrical field stimulation (EFS) in the rabbit ...
Zygmunt, P.M., P.K.E. Zygmunt, K.‐E. Andersson, Högestätt, E. D.,, Högestätt, E. D., Zygmunt, P.M.,, Andersson, K. ‐E, Zygmunt, P. K.E., P.M. Zygmunt, E.D. Högestätt, Zygmunt, P. K.E.,, Lund University., Andersson, K. ‐E,   +12 more
core   +1 more source

Properties of ω conotoxin MVIIC receptors associated with α1A calcium channel subunits in rat brain [PDF]

, 1995
Solubilized 125I-ω conotoxin MVIIC receptors from rat cerebellum were immunoprecipitated by antibodies directed against the calcium channel α1A subunit.
Leveque, Christian, Takahashi, Masami, Seagar, Michael, Sato, Kazuki, Martin-Moutot, Nicole, Kato, Rika   +5 more
core   +1 more source

High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing

Marine Drugs, 2019
The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative ...
Ge Yao, Chao Peng, Yabing Zhu, Chongxu Fan, Hui Jiang, Jisheng Chen, Ying Cao, Qiong Shi   +7 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii

Marine Drugs, 2016
Toxins that are secreted by cone snails are small peptides that are used to treat several diseases. However, their effects on parasites with human and veterinary significance are unknown.
Marco A. De León-Nava, Eunice Romero-Núñez, Angélica Luna-Nophal, Johanna Bernáldez-Sarabia, Liliana N. Sánchez-Campos, Alexei F. Licea-Navarro, Jorge Morales-Montor, Saé Muñiz-Hernández   +7 more
doaj   +1 more source

A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus)

Marine Drugs, 2017
Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels.
Yu Huang, Chao Peng, Yunhai Yi, Bingmiao Gao, Qiong Shi   +4 more
doaj   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source