Results 81 to 90 of about 24,889 (220)
Folding of small disulfide-rich proteins : clarifying the puzzle [PDF]
, 2006 Premi a l'excel·lència investigadora. Àmbit de les Ciències Experimentals. 2008The process by which small proteins fold to their native conformations has been intensively studied over the last few decades.
Apuy +73 more
core +2 more sources
Conotoxins: Therapeutic Potential and Application
Marine Drugs, 2006 The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley +1 more source
Stapling Cysteine[2,4] Disulfide Bond of α-Conotoxin LsIA and Its Potential in Target Delivery
Marine Drugsα-Conotoxins, as selective nAChR antagonists, can be valuable tools for targeted drug delivery and fluorescent labeling, while conotoxin-drug or conotoxin-fluorescent conjugates through the disulfide bond are rarely reported.
Xin Sun +6 more
doaj +1 more source
α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t
Toxins, 2017 Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD) spectroscopy and mass spectrometry (MS) were used to assess the effect of each chemical ...
Matthew W. Turner +2 more
doaj +1 more source
The Potential Role of Calcium Channels in Pulmonary Hypertension
BioMed Research International, Volume 2026, Issue 1, 2026.Pulmonary hypertension (PH) is a severe cardiovascular syndrome characterized by progressively elevated pulmonary arterial pressure and driven pathologically by sustained vasoconstriction and irreversible vascular remodeling. Growing evidence underscores the central role of calcium ion (Ca2+) signaling networks in PH pathogenesis, which dynamically ...
Ping Wu +5 more
wiley +1 more source
Marine Drugs, 2019 The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li +6 more
doaj +1 more source
Biological activities of aqueous and organic extracts from tropical marine sponges [PDF]
, 2010 We report on screening tests of 66 extracts obtained from 35 marine sponge species from the Caribbean Sea (Curaçao) and from eight species from the Great Barrier Reef (Lizard Island). Extracts were prepared in aqueous and organic solvents and were tested
Sepčić, Kristina +3 more
core +2 more sources
MedComm, Volume 6, Issue 12, December 2025.Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li +13 more
wiley +1 more source
Less is more: Design of a highly stable disulfide-deleted mutant of analgesic cyclic alpha-conotoxin Vc1.1 [PDF]
, 2015 Cyclic alpha-conotoxin Vc1.1 (cVc1.1) is an orally active peptide with analgesic activity in rat models of neuropathic pain. It has two disulfide bonds, which can have three different connectivities, one of which is the native and active form.
Adams, D +7 more
core +3 more sources