Results 91 to 100 of about 21,330 (214)
Solution structure of ω-conotoxin MVIIA using 2D NMR spectroscopy
, 1995 The solution structure of ω-conotoxin MVIIA (SNX-111), a peptide toxin from the fish hunting cone snail Conus magus and a high-affinity blocker of N-type calcium channels, was determined by 2D NMR spectroscopy.
Vladimir J. Basus +7 more
core +1 more source
Marine Drugs, 2017 Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels.
Yu Huang +4 more
doaj +1 more source
, 1990 Monoclonal antibodies have been prepared against co-conotoxin GVI A, a peptide isolated from marine snails of the genus Conus (Conus geographus and Conus magus).
Feuerstein, G. +7 more
core +1 more source
Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors [PDF]
, 2013 Background: -Conotoxin AuIB interacts with 34 nAChRs and GABA(B) receptors, but structural determinants of these interactions are unknown. Results: Using alanine scanning mutagenesis and molecular dynamics, we identified residues crucial for AuIB34 nAChR
Akondi, Kalyana +8 more
core +1 more source
MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I
, 1996 1. A 31-amino-acid peptide from the venom of the snail-hunting species Conus marmoreus, microO-conotoxin MrVIA, inhibits mammalian voltage-gated sodium channels through a novel mechanism distinct from saxitoxin, tetrodotoxin, or mu-conotoxin. 2.
H. Terlau +4 more
core +1 more source
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery
Toxins, 2017 Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao +5 more
doaj +1 more source
‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency
Marine Drugs, 2019 Integrated venomics techniques have shown that variable processing of conotoxins from Conus marmoreus resulted in a dramatic expansion in the number of expressed conotoxins. One conotoxin from C.
Rebekah Ziegman +5 more
doaj +1 more source
Toxins, 2019 Species interactions are fundamental ecological forces that can have significant impacts on the evolutionary trajectories of species. Nonetheless, the contribution of predator-prey interactions to genetic and phenotypic divergence remains largely unknown.
David A. Weese, Thomas F. Duda
doaj +1 more source
Molecular determinants of μ-conotoxin block of single sodium channels
, 2000 incomplete title - a symbol in front of 'conotoxin', not recognized in the Gencat databaseBibliography: p.
Hui, Kwokyin
core +1 more source
Three-Dimensional Solution Structure of ω-Conotoxin TxVII, an L-Type Calcium Channel Blocker†,‡
, 2016 We determined the three-dimensional structure of ω-conotoxin TxVII, a 26-residue peptide that is an L-type calcium channel blocker, by 1H NMR in aqueous solution.
Kuniko Kobayashi (2432062) +3 more
core +1 more source