Results 91 to 100 of about 22,310 (212)

Direct Heterologous Expression of Cyclic Conotoxin [G22N]Vc1.1 in Yeast

Backbone-cyclized conotoxin Vc1.1 is a potent GABAB receptor agonist and analgesic drug lead for treating neuropathic pain. Here, we describe two yeast-based strategies for the direct recombinant production of this cyclic, disulfide-rich peptide.
Kuok Yap, Thomas Durek, David J. Craik, Jing Xie, Conan K. Wang   +4 more
core   +1 more source

Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery

Toxins, 2017
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao, Chao Peng, Jiaan Yang, Yunhai Yi, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I

, 1996
1. A 31-amino-acid peptide from the venom of the snail-hunting species Conus marmoreus, microO-conotoxin MrVIA, inhibits mammalian voltage-gated sodium channels through a novel mechanism distinct from saxitoxin, tetrodotoxin, or mu-conotoxin. 2.
H. Terlau, J. M. McIntosh, B. M. Olivera, K. J. Shon, M. Stocker   +4 more
core   +1 more source

‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

Marine Drugs, 2019
Integrated venomics techniques have shown that variable processing of conotoxins from Conus marmoreus resulted in a dramatic expansion in the number of expressed conotoxins. One conotoxin from C.
Rebekah Ziegman, Andreas Brust, Prerna Jha, Fernanda C. Cardoso, Richard J. Lewis, Paul F. Alewood   +5 more
doaj   +1 more source

Effects of Predator-Prey Interactions on Predator Traits: Differentiation of Diets and Venoms of a Marine Snail

Toxins, 2019
Species interactions are fundamental ecological forces that can have significant impacts on the evolutionary trajectories of species. Nonetheless, the contribution of predator-prey interactions to genetic and phenotypic divergence remains largely unknown.
David A. Weese, Thomas F. Duda
doaj   +1 more source

Three-Dimensional Solution Structure of ω-Conotoxin TxVII, an L-Type Calcium Channel Blocker^†,‡

, 2016
We determined the three-dimensional structure of ω-conotoxin TxVII, a 26-residue peptide that is an L-type calcium channel blocker, by 1H NMR in aqueous solution.
Kuniko Kobayashi (2432062), Toru Sasaki (2945262), Toshiyuki Kohno (1283901), Kazuki Sato (3597)   +3 more
core   +1 more source

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

Toxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel, Johanna Bernáldez, Samanta Jiménez, Beatrix Ueberhide, Luis Javier González, Alexei Licea-Navarro   +5 more
doaj   +1 more source

α-Conotoxins

The International Journal of Biochemistry & Cell Biology, 2000
Fil: Blanton, Michael P.
Arias, Hugo Rubén, Blanton, Michael P
openaire   +2 more sources

Molecular determinants of μ-conotoxin block of single sodium channels

, 2000
incomplete title - a symbol in front of 'conotoxin', not recognized in the Gencat databaseBibliography: p.
Hui, Kwokyin
core   +1 more source

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs

Marine Drugs, 2016
Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Shihua Xiang, Mengsen Li
doaj   +1 more source