Results 111 to 120 of about 21,330 (214)

Conotoxins.

Journal of Biological Chemistry, 1991
B M, Olivera, J, Rivier, J K, Scott, D R, Hillyard, L J, Cruz   +4 more
openaire   +2 more sources

Enhancing Stability and Albumin Binding Efficiency of α‑Conotoxin GI through Fatty Acid Modification

α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Quankuo He (17398282), Jianying Dong (14979244), Yuanyuan Lian (8364879), Panpan Qi (3255048), Junjie Zhang (355622), Sulan Luo (277905), Ting Xie (191025), Dongting Zhangsun (277907), Yong Wu (165587)   +8 more
core   +1 more source

Solution structure of αA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus

, 2003
journal articleWe report the solution three-dimensional structure of an αA-conotoxin EIVA determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
Chi, Seung-Wook; Park, Kyu-Hwan; Suk, Jae-Eun; Han, Kyou-Hoon, Olivera, Baldomero M.; McIntosh, J. Michael   +1 more
core  

NMR Structure Determination of a Novel Conotoxin, [Pro 7,13] αA-Conotoxin P_IVA^†,‡

, 2016
A high-resolution solution conformation of a novel conotoxin, [Pro 7,13] αA-conotoxin PIVA, GCCGSYPNAACHPCSCKDROSYCGQ-NH2, has been determined by two-dimensional 1H NMR methods and distance geometry calculations.
Jean Rivier (355982), Soo-Kyung Kim (1632286), Kyou-Hoon Han (555554), Kae-Jung Hwang (2948937), Seung-Moak Kim (2948928), William R. Gray (2948934), Baldomero M. Olivera (369455), Ki-Joon Shon (2948931)   +7 more
core   +1 more source

Omega-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Ca(v)2.2 Ion Channels

, 2012
The neuronal voltage-gated N-type calcium channel (Ca(v)2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived omega-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared ...
Aijun Yang (694090), Richard Lewis (1612549), Kellie Tuck (20028918), Charlotte Tranberg (20028912), I Vetter (13721578), J Baell (13632106), Jeffrey McArthur (20028915), P Duggan (13721587)   +7 more
core  

Comparative analysis of venom genes in the chromosome-level genomes of two closely related cone snails. [PDF]

BMC Genomics
Herráez-Pérez A, Zardoya R.
europepmc   +1 more source

A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides. [PDF]

Commun Chem
Ge C, Tae HS, Lu L, Zhang Z, Huang Z, An B, Wang Y, Jiang T, Cai W, Chang S, Adams DJ, Yu R.   +11 more
europepmc   +1 more source

Gene expression, purification, and functional characterization of recombinant conotoxin μ-TIIIA and TIIIAlaMut in Escherichia coli with clinical evaluation of antiwrinkle efficacy. [PDF]

BioTechnologia (Pozn)
Mikiewicz D, Mazurkiewicz-Pisarek A, Janczewska M, De Waele J, Mazurkiewicz A, Stefanek A, Bosmans F, Lew-Mirska A, Styczeń P, Ciach T.   +9 more
europepmc   +1 more source

ĸ-Conotoxin PVIIA is a peptide inhibiting the Shaker K+ channel

, 1998
journal articleĸ-Conotoxin PVIIA (k-PVIIA), a 27-amino acid toxin from Conus purpurascens venom that inhibits the Shaker potassium channel, was chemically synthesized in a biologically active form.
Olivera, Baldomero M.; Hillyard, David R.; Gray, William Robert, Shon, Ki-Joon; Stocker, Martin; Terlau, Heinrich; Stühmer, Walter; Jacobsen, Richard; Walker, Craig; Grilley, Michelle; Watkins, Maren   +1 more
core  

Ancestral Sequence Reconstruction Provides Insights into the Structural Diversification and Neofunctionalization of T-superfamily Conotoxins in Conus. [PDF]

Mol Biol Evol
Espino SS, Koch TL, Gajewiak J, Giglio ML, Watkins M, Safavi-Hemami H, Olivera BM.   +6 more
europepmc   +1 more source