Results 111 to 120 of about 24,889 (220)

Effects of Predator-Prey Interactions on Predator Traits: Differentiation of Diets and Venoms of a Marine Snail

open access: yesToxins, 2019
Species interactions are fundamental ecological forces that can have significant impacts on the evolutionary trajectories of species. Nonetheless, the contribution of predator-prey interactions to genetic and phenotypic divergence remains largely unknown.
David A. Weese, Thomas F. Duda
doaj   +1 more source

Commentary: Nicotinic acetylcholine receptor α9 and α10 subunits are expressed in the brain of mice [PDF]

open access: yes, 2018
Fil: Morley, Barbara J.. Boys Town National Research Hospita; Estados UnidosFil: Whiteaker, Paul. Barrow Neurological Institute; Estados UnidosFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas.
Elgoyhen, Ana Belen   +2 more
core   +1 more source

Total chemical synthesis of a heterodimeric interchain Bis-Lactam-linked peptide: application to an analogue of human insulin-like peptide 3 [PDF]

open access: yes, 2013
Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary conformation of the peptide while simultaneously extending the in vitro and in vivo half-life of the biomolecule.
Gardiner, J.   +6 more
core   +3 more sources

Novel conopeptides of largely unexplored Indo Pacific Conus sp. [PDF]

open access: yes, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
D'Souza, L.   +9 more
core  

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

open access: yesToxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel   +5 more
doaj   +1 more source

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs

open access: yesMarine Drugs, 2016
Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Shihua Xiang, Mengsen Li
doaj   +1 more source

Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]

open access: yes, 2018
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Favreau, P.   +4 more
core  

Identification of “alpha-conotoxin-like” Peptide in Conus pennaceus Born, 1778, Venom [PDF]

open access: yesبوم‌شناسی آبزیان, 2018
Conic snails are slow-moving carnivorous that use a very powerful venom to hunt. This venom is a combination of different toxins from the family of conototoxins.
Hadi Dehghani   +4 more
doaj  

Molecular basis for Ca2+ channel diversity [PDF]

open access: yes, 1994
Biel, Martin   +2 more
core   +1 more source

Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]

open access: yes, 2010
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M.   +8 more
core  

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