Results 111 to 120 of about 22,310 (212)

Solution structure of αA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus

, 2003
journal articleWe report the solution three-dimensional structure of an αA-conotoxin EIVA determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
Chi, Seung-Wook; Park, Kyu-Hwan; Suk, Jae-Eun; Han, Kyou-Hoon, Olivera, Baldomero M.; McIntosh, J. Michael   +1 more
core  

From Marine Peptides to Oncology: The Therapeutic Potential of Conotoxins in Cancer Treatment. [PDF]

Chem Biodivers
Awais S, Javed MA, Ali R, Shahid M, Shahid MA, Masaud H, Ali N.   +6 more
europepmc   +1 more source

ĸ-Conotoxin PVIIA is a peptide inhibiting the Shaker K+ channel

, 1998
journal articleĸ-Conotoxin PVIIA (k-PVIIA), a 27-amino acid toxin from Conus purpurascens venom that inhibits the Shaker potassium channel, was chemically synthesized in a biologically active form.
Olivera, Baldomero M.; Hillyard, David R.; Gray, William Robert, Shon, Ki-Joon; Stocker, Martin; Terlau, Heinrich; Stühmer, Walter; Jacobsen, Richard; Walker, Craig; Grilley, Michelle; Watkins, Maren   +1 more
core  

From neuropeptides to toxins: illuminating the origins of venom complexity in cone snails. [PDF]

Mol Biol Evol
Koch TL, Ferrari G, Sumanam SB, Salcedo PF, Watkins M, Chase K, Tooming-Klunderud A, Lluisma AO, Yanagihara A, Young ND, Olivera BM, Undheim EAB, Safavi-Hemami H.   +12 more
europepmc   +1 more source

αO-Conotoxin GeXIVA[1,2] Attenuates Paclitaxel-Induced Neurotoxicity by Suppressing Ferroptosis via the Nrf2/SLC7A11/GSH/GPX4 Pathway. [PDF]

Mar Drugs
Liu D, Yu J, Xu W, Shen Y, Feng X, Li X, Luo S, Bao J, Ding RB.   +8 more
europepmc   +1 more source

From marine predator to pharmacology: Conotoxin diversity, discovery, and therapeutic potential. [PDF]

Zool Res
Mao KL, Fu JX, Chen J, Liao YL, Huang ML, Chen Z, Lin LM, Shi Q, Gao BM.   +8 more
europepmc   +1 more source

Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter. [PDF]

Nat Struct Mol Biol
Belleza OJV, Zhang H, Schmidhammer H, Gonzalez TI, Ciotu CI, Tomašević N, Ocampo CMM, Fernando JC, Koehbach J, Schwarz P, Al Makhlouf M, Tajti G, Hasinger S, Kastner N, Avsar O, Retzl B, Jäntsch K, Jiang Y, Hellinger R, Fischer MJM, Rosengren KJ, Gruber CW, Villaraza AJL, Stockner T, Spetea M, Xu HE, Sitte HH.   +26 more
europepmc   +1 more source

Comparative analysis of venom genes in the chromosome-level genomes of two closely related cone snails. [PDF]

BMC Genomics
Herráez-Pérez A, Zardoya R.
europepmc   +1 more source

A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides. [PDF]

Commun Chem
Ge C, Tae HS, Lu L, Zhang Z, Huang Z, An B, Wang Y, Jiang T, Cai W, Chang S, Adams DJ, Yu R.   +11 more
europepmc   +1 more source

Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition. [PDF]

J Clin Invest
Arnold WD, Jeppesen Morgen J, Thomasen PB, Broch-Lips M, Clark LA, Groennebaek T, Skov M, Winther JB, Ramadan A, Rust PA, Myers JH, Darvishi FB, Dashtmian AR, Fish LA, Chugh D, Bold J, Quiroz J, Hutchison J, Nishimune H, Jones RA, Wang X, Fallon JR, Gillingwater TH, Rich MM, Pedersen TH, Clark BC.   +25 more
europepmc   +1 more source