Results 101 to 110 of about 22,310 (212)
Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors [PDF]
, 2013 Background: -Conotoxin AuIB interacts with 34 nAChRs and GABA(B) receptors, but structural determinants of these interactions are unknown. Results: Using alanine scanning mutagenesis and molecular dynamics, we identified residues crucial for AuIB34 nAChR
Akondi, Kalyana +8 more
core +1 more source
Omega-Conotoxin prevents the effect of adrenocorticotropin in hypovolemic shock
, 1992 Omega-Conotoxin prevents the effect of adrenocorticotropin in hypovolemic ...
BAZZANI, Carla +2 more
core
Stability and Structure-Forming Properties of the Two Disulfide Bonds of α-Conotoxin GI
, 2016 α-Conotoxin GI is a 13 residue snail toxin peptide cross-linked by Cys2−Cys7 and Cys3−Cys13 disulfide bridges. The formation of the two disulfide bonds by thiol/disulfide exchange with oxidized glutathione (GSSG) has been characterized.
Andreas Kaerner (2140825) +1 more
core +1 more source
Identification of “alpha-conotoxin-like” Peptide in Conus pennaceus Born, 1778, Venom [PDF]
بومشناسی آبزیان, 2018 Conic snails are slow-moving carnivorous that use a very powerful venom to hunt. This venom is a combination of different toxins from the family of conototoxins.
Hadi Dehghani +4 more
doaj
, 2018 To expand our capacity to discover venom sequences from the genomes of venomous organisms, we applied targeted sequencing techniques to selectively recover venom gene superfamilies and non-toxin loci from the genomes of 32 cone snail species (family ...
Phuong, Mark A., Mahardika, Gusti N.
core +1 more source
Discovery of novel conotoxin candidates using machine learning
, 2018 Cone snails (genus ) are venomous marine snails that inject prey with a lethal cocktail of conotoxins, small, secreted, and cysteine-rich peptides.
Samuel D. Robinson +10 more
core +1 more source
Enhancing Stability and Albumin Binding Efficiency of α‑Conotoxin GI through Fatty Acid Modification
α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Quankuo He (17398282) +8 more
core +1 more source
, 1989 1 It has been suggested that neuronal voltage-sensitive calcium channels (VSCC) may be divided into dihydropyridine (DHP)-sensitive (L) and DHP-insensitive (N and T), and that both the L and the N type channels are attenuated by the peptide blocker ω ...
BOARDER, M R, MARRIOTT, D B, OWEN, P J
core +2 more sources
Omega-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Ca(v)2.2 Ion Channels
, 2012 The neuronal voltage-gated N-type calcium channel (Ca(v)2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived omega-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared ...
Aijun Yang (694090) +7 more
core