Results 61 to 70 of about 22,310 (212)

Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Disulfide‐rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80‐residue proteins conserved across gastropods that form a long‐standing orphan family whose structure and biological roles have remained unknown.
Oleg Melnyk, Stéphanie Caby, Armelle Vigouroux, Christine Demanche, Rémi Desmet, Magalie Sénéchal, Benoît Snella, Alexandra Mougel, Céline Boidin‐Wichlacz, Aurélie Parmentier, Ugo Pasco, Sonia Cantel, Solange Moréra, Jérôme Vicogne   +13 more
wiley   +1 more source

Conotoxins: Therapeutic Potential and Application

Marine Drugs, 2006
The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj   +1 more source

Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis

Frontiers in Marine Science, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Yinbin Qiu, Yinbin Qiu, Yinbin Qiu, Fahui Gong, Baoting Nong, Xinghua Pan, Xinghua Pan, Xinghua Pan   +11 more
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Solution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors

, 2004
α-Conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. α-Conotoxin GIC potently blocks the α3β2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [
Do-Hyoung Kim, Seung-Wook Chi, Kyou Hoon Han, J M McIntosh, B M Olivera   +4 more
core   +1 more source

Monoclonal antibodies against the presynaptic calcium channel antagonist ω-conotoxin GVI A from cone snail poison [PDF]

, 1990
Monoclonal antibodies have been prepared against co-conotoxin GVI A, a peptide isolated from marine snails of the genus Conus (Conus geographus and Conus magus).
Feuerstein, G., G. Feuerstein, O.M. Adeyemo, Tombaccini, D., Pollard, H.B., D. Tombaccini, H.B. Pollard, Adeyemo, O.M.   +7 more
core   +1 more source

α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t

Toxins, 2017
Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD) spectroscopy and mass spectrometry (MS) were used to assess the effect of each chemical ...
Matthew W. Turner, John R. Cort, Owen M. McDougal   +2 more
doaj   +1 more source

Efficacy of sodium channel blockers in treating myotonia is independent of action potential sodium current block

The Journal of Physiology, Volume 604, Issue 18, Page 7799-7818, 15 September 2026.
Abstract figure legend Contrary to the prevailing view, the therapeutic efficacy of sodium channel blockers in myotonia does not depend on inhibition of the transient sodium current (NaT) responsible for action potentials. In a mouse model of myotonia congenita, effective concentrations of sodium channel blockers did not reduce NaT, but consistently ...
Phil Walker, Brent Foy, Xueyong Wang, Kaylee M. Pham, Jess Myers, Chris Dupont, Samantha Kohli, Adam S. Deardorff, Andrew A. Voss, Mark M. Rich   +9 more
wiley   +1 more source

Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes

Marine Drugs, 2019
The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li, Michaël Bekaert, Luning Wu, Changkao Mu, Weiwei Song, Herve Migaud, Chunlin Wang   +6 more
doaj   +1 more source

Recombinant expression and insecticidal properties of a Conus ventricosus conotoxin-GST fusion protein

, 2012
""A novel conotoxin, conotoxin Vn2, was recently isolated from the venom of Conus ventricosus, a worm-hunting cone snail species living in the Mediterranean Sea.
Spiezia MC, CHIARABELLI, Cristiano, POLTICELLI, Fabio   +2 more
core   +1 more source