Results 61 to 70 of about 21,330 (214)

omega-Conotoxin GVIA binds to and blocks rat neuromuscular junction

, 1994
The effect of omega-conotoxin GVIA, a specific blocker of N-type calcium channels, on the synaptic transmission at the mammalian neuromuscular junction is controversial. We have found that 125I-omega-conotoxin binds to rat tibialis muscle end-plate; that
L. La Maestra, F. Berti, F. Clementi, G. Rossoni   +3 more
core   +1 more source

Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins

Toxins
µ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development.
Kirsten L. McMahon, Irina Vetter, Christina I. Schroeder   +2 more
doaj   +1 more source

NMR structure determination of a novel conotoxin, [Pro 7,13] αA-conotoxin Piva

, 1997
A high-resolution solution conformation of a novel conotoxin, [Pro 7,13] αA-conotoxin P(IVA), GCCGSYPNAACHPCSCKDROSYCGQ-NH2, has been determined by two-dimensional 1H NMR methods and distance geometry calculations.
Kyou Hoon Han, W R Gray, J Rivier, Kae-Jung Hwang, B M Olivera, Soo-Kyung Kim, Seung Moak Kim, Ki-Joon Shon   +7 more
core   +1 more source

Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail

Toxins, 2017
Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao, Chao Peng, Bo Lin, Qin Chen, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis

Frontiers in Marine Science, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Yinbin Qiu, Yinbin Qiu, Yinbin Qiu, Fahui Gong, Baoting Nong, Xinghua Pan, Xinghua Pan, Xinghua Pan   +11 more
doaj   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Solution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors

, 2004
α-Conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. α-Conotoxin GIC potently blocks the α3β2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [
Do-Hyoung Kim, Seung-Wook Chi, Kyou Hoon Han, J M McIntosh, B M Olivera   +4 more
core   +1 more source

Conotoxins: Therapeutic Potential and Application

Marine Drugs, 2006
The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj   +1 more source

α-Conotoxins

The International Journal of Biochemistry & Cell Biology, 2000
Fil: Blanton, Michael P.
Arias, Hugo Rubén, Blanton, Michael P
openaire   +2 more sources

Recombinant expression and insecticidal properties of a Conus ventricosus conotoxin-GST fusion protein

, 2012
""A novel conotoxin, conotoxin Vn2, was recently isolated from the venom of Conus ventricosus, a worm-hunting cone snail species living in the Mediterranean Sea.
Spiezia MC, CHIARABELLI, Cristiano, POLTICELLI, Fabio   +2 more
core   +1 more source