Results 21 to 30 of about 22,310 (212)

Systematic dissection of genomic features determining the vast diversity of conotoxins

BMC Genomics, 2023
Background Conus, a highly diverse species of venomous predators, has attracted significant attention in neuroscience and new drug development due to their rich collection of neuroactive peptides called conotoxins.
Jian-Wei Zheng, Yang Lu, Yu-Feng Yang, Dan Huang, Da-Wei Li, Xiang Wang, Yang Gao, Wei-Dong Yang, Yuanfang Guan, Hong-Ye Li   +9 more
doaj   +1 more source

High conopeptide diversity in Conus striatus: Revealed by integration of two transcriptome sequencing platforms

Frontiers in Marine Science, 2022
Marine cone snail venoms represent a vast library of bioactive peptides with proven potential as research tools, drug leads, and therapeutics. In this study, a transcriptome library of four different organs, namely radular sheath, venom duct, venom gland,
Yanling Liao, Chao Peng, Chao Peng, Yabing Zhu, Jinxing Fu, Zhiqiang Ruan, Qiong Shi, Qiong Shi, Bingmiao Gao   +8 more
doaj   +1 more source

Graph-Directed Approach for Downselecting Toxins for Experimental Structure Determination

Marine Drugs, 2020
Conotoxins are short, cysteine-rich peptides of great interest as novel therapeutic leads and of great concern as lethal biological agents due to their high affinity and specificity for various receptors involved in neuromuscular transmission. Currently,
Rachael A. Mansbach, Srirupa Chakraborty, Timothy Travers, S. Gnanakaran   +3 more
doaj   +1 more source

A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity

Acta Pharmaceutica Sinica B, 2021
ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which consists
Jinqin Chen, Xinhong Liu, Shuo Yu, Jia Liu, Rongfang Chen, Yunxiao Zhang, Ling Jiang, Qiuyun Dai   +7 more
doaj   +1 more source

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity [PDF]

, 2007
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack ...
Sixma, Titia K., Alewood, Paul F., Buettner, Regina, van Elk, R, Smit, A.B., Sixma, T., Dutertre, S., Nicke, A, van Elk, R., Smit, A., Nicke, Annette, Alewood, P. F., Sixma, T.K., Kendel, Y., Smit, AB, Lewis, R. J., Hopping, G., Kendel, Y, van Elk, René, Büttner, Regina, Elk, René van, Ulens, C, Ulens, Chris, Buttner, R, Kendel, Yvonne, Sixma, TK, Fish, Alexander, Lewis, R.J., Schroeder, Christina, Lewis, Richard,, Smit, August,, Buttner, R., Elk, R. van, Alewood, P.F., Lewis, Richard J., Fish, A, Sixma, Titia,, Schroeder, C., Alewood, Paul,, Fish, A., Alewood, P., Dutertre, Sébastien, Smit, August B., Ulens, C., Hopping, Gene, Nicke, A., Lewis, R.   +46 more
core   +1 more source

Principal Component and Structural Element Analysis Provide Insights into the Evolutionary Divergence of Conotoxins

Biology, 2022
Predatory cone snails (Conus) developed a sophisticated neuropharmacological mechanism to capture prey, escape against other predators, and deter competitors.
Akira Kio V. Kikuchi, Lemmuel L. Tayo
doaj   +1 more source

Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus

Marine Drugs, 2021
Conotoxins are disulfide-rich peptides found in the venom of cone snails. Due to their exquisite potency and high selectivity for a wide range of voltage and ligand gated ion channels they are attractive drug leads in neuropharmacology.
David A. Armstrong, Ai-Hua Jin, Nayara Braga Emidio, Richard J. Lewis, Paul F. Alewood, K. Johan Rosengren   +5 more
doaj   +1 more source

Glycosylation of Conotoxins

Marine Drugs, 2013
Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite ...
Gerwig, G.J., Hocking, H.G., Stöcklin, R., Kamerling, J.P., Boelens, R.   +4 more
openaire   +5 more sources

The T-superfamily of Conotoxins [PDF]

Journal of Biological Chemistry, 1999
Nous rapportons la découverte et la caractérisation initiale de la super-famille T des conotoxines. Huit peptides différents de la superfamille T de cinq espèces de Conus ont été identifiés ; ils partagent une séquence de signal consensuelle et un arrangement conservé de résidus de cystéine (- -CC- -CC-).
Colin Walker, Douglas J. Steel, Richard B. Jacobsen, Marcelina B. Lirazan, Lourdes J. Cruz, David K. Hooper, Reshma Shetty, Richard C. DelaCruz, Jimmi Nielsen, Li Zhou, Pradip K. Bandyopadhyay, A. Grey Craig, Baldomero M. Olivera   +12 more
openaire   +2 more sources

Structural studies of conotoxins [PDF]

IUBMB Life, 2009
AbstractConotoxins are small disulfide‐rich peptides from the venoms of marine cone snails. They target a variety of ion channels, transporters, and receptors besides the interest in their natural functions in venoms and they are of much interest as drug leads.
Daly, Norelle L., Craik, David J.
openaire   +5 more sources