Results 21 to 30 of about 21,330 (214)
Geographic Variation in Diet and Genetic Connectivity of Populations of the Widespread Predatory Cone Snail <i>Conus miliaris</i>. [PDF]
Ecol EvolWe examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Duda TF, Vergara-Flórez DC.
europepmc +2 more sources
Graph-Directed Approach for Downselecting Toxins for Experimental Structure Determination
Marine Drugs, 2020 Conotoxins are short, cysteine-rich peptides of great interest as novel therapeutic leads and of great concern as lethal biological agents due to their high affinity and specificity for various receptors involved in neuromuscular transmission. Currently,
Rachael A. Mansbach +3 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2021 ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which consists
Jinqin Chen +7 more
doaj +1 more source
The T-superfamily of Conotoxins [PDF]
Journal of Biological Chemistry, 1999 Nous rapportons la découverte et la caractérisation initiale de la super-famille T des conotoxines. Huit peptides différents de la superfamille T de cinq espèces de Conus ont été identifiés ; ils partagent une séquence de signal consensuelle et un arrangement conservé de résidus de cystéine (- -CC- -CC-).
Colin Walker +12 more
openaire +2 more sources
Characterisation of a Novel A-Superfamily Conotoxin [PDF]
Biomedicines, 2020 Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine receptor (nAChR) subtypes.
David T. Wilson +6 more
openaire +6 more sources
Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite ...
Gerwig, G.J. +4 more
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Structural studies of conotoxins [PDF]
IUBMB Life, 2009 AbstractConotoxins are small disulfide‐rich peptides from the venoms of marine cone snails. They target a variety of ion channels, transporters, and receptors besides the interest in their natural functions in venoms and they are of much interest as drug leads.
Daly, Norelle L., Craik, David J.
openaire +5 more sources
Biology, 2022 Predatory cone snails (Conus) developed a sophisticated neuropharmacological mechanism to capture prey, escape against other predators, and deter competitors.
Akira Kio V. Kikuchi, Lemmuel L. Tayo
doaj +1 more source
Conotoxins and their regulatory considerations [PDF]
Regulatory Toxicology and Pharmacology, 2014 Venom derived peptides from marine cone snails, conotoxins, have demonstrated unique pharmacological targeting properties that have been pivotal in advancing medical research. The awareness of their true toxic origins and potent pharmacological nature is emphasized by their 'select agent' classification by the US Centers for Disease Control and ...
Parashar Thapa +3 more
openaire +3 more sources
Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus
Marine Drugs, 2021 Conotoxins are disulfide-rich peptides found in the venom of cone snails. Due to their exquisite potency and high selectivity for a wide range of voltage and ligand gated ion channels they are attractive drug leads in neuropharmacology.
David A. Armstrong +5 more
doaj +1 more source