Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus
Marine Drugs, 2022 The venom duct transcriptomes and proteomes of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus were obtained and compared.
José Ramón Pardos-Blas +3 more
doaj +1 more source
Toxins, 2022 We isolated a new dimeric conotoxin with inhibitory activity against neuronal nicotinic acetylcholine receptors. Edman degradation and transcriptomic studies indicate a homodimeric conotoxin composed by two chains of 47 amino acid in length.
Ximena C. Rodriguez-Ruiz +4 more
doaj +1 more source
Geographic Variation in Diet and Genetic Connectivity of Populations of the Widespread Predatory Cone Snail <i>Conus miliaris</i>. [PDF]
Ecol EvolWe examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Duda TF, Vergara-Flórez DC.
europepmc +2 more sources
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background: Diverse and unique bioactive neurotoxins known as conopeptides or conotoxins are produced by venomous marine cone snails. Currently, these small and stable molecules are of great importance as research tools and platforms for discovering new ...
Maged M. A. Fouda +4 more
doaj +1 more source
Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR
Marine Drugs, 2020 Conotoxin-Ac1 and its variant conotoxin-Ac1-O6P, were isolated from the venom duct of Conus achatinus, a fish-hunting cone snail species collected in the Sea of Hainan, China. Conotoxin-Ac1 is linear peptide that contain 15 amino acids.
Xiujie Liu +5 more
doaj +1 more source
Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. [PDF]
PLoS ONE, 2013 Cone snails, which are predatory marine gastropods, produce a cocktail of venoms used for predation, defense and competition. The major venom component, conotoxin, has received significant attention because it is useful in neuroscience research, drug ...
Yun Wu +9 more
doaj +1 more source
Marine Drugs, 2021 Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajesh Rajaian Pushpabai +4 more
doaj +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background Conotoxins have become a research hotspot in the neuropharmacology field for their high activity and specificity in targeting ion channels and neurotransmitter receptors.
Manyi Yang +3 more
doaj +1 more source
α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons. [PDF]
J PhysiolAbstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Tomagra G +12 more
europepmc +2 more sources
Systematic dissection of genomic features determining the vast diversity of conotoxins
BMC Genomics, 2023 Background Conus, a highly diverse species of venomous predators, has attracted significant attention in neuroscience and new drug development due to their rich collection of neuroactive peptides called conotoxins.
Jian-Wei Zheng +9 more
doaj +1 more source