Results 111 to 120 of about 290,776 (322)
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
United States Pharmacopeial Convention (USP)
Регуляторные исследования и экспертиза лекарственных средств, 2018 The United States Pharmacopeial Convention (USP) is a non-profit, non-governmental public health organization that creates documentary and material reference standards for prescription and over-the-counter medicines that are recognized in United States ...
Ronald T. Piervincenzi
doaj
LEGISLATIVE ASPECTS CONCERNING THE LEATHER WASTES [PDF]
Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2017 This paper underlines the current legislation and compliance issues leather waste in different waste groups according to relevant legislation and shows that, although seemingly harmless waste of skin sometimes contain dangerous compounds.
TIMOFTE Claudia Simona, TRIPA Simona
doaj
Non-conventional Superconductors and Percolation [PDF]
arXiv, 2011 This paper presents a novel theory for understanding the mechanics behind non-conventional superconductors. It presents the hypothesis that non-conventional superconductors are 2D lattices of super-cells and that the superconductivity mechanism involves the ordered hopping of itinerant electrons along with phase transitions in the edge percolations.
arxiv
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Dilemmas and trade-offs in the diffusion of conventions [PDF]
arXivOutside ideal settings, conventions are shaped by competing processes that can challenge the emergence of norms. This paper identifies three trade-offs challenging the diffusion of conventions: (I) the trade-off between the imperatives of social, sequential, and contextual consistency that individuals balance when choosing between conventions; (II) the
arxiv
The Competitiveness of On-Line vis-a-vis Conventional Retailing: A Preliminary Study [PDF]
arXiv, 2000 Previous research has directly studied whether on-line retailing is more competitive than conventional retail markets. The evidence from books and music CDs is mixed. Here, I use an indirect approach to compare the competitiveness of on-line with conventional markets.
arxiv
Molecular Oncology, EarlyView.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source