Results 111 to 120 of about 25,875 (290)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Science, values and people: The three factors that will define that next generation of international conservation agreements [PDF]

, 2012
This brief paper is concerned with three emerging issues that will, individually and collectively, define the way in which international conservation law moves forward in the coming decades.
Gillespie, Alexander
core   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Regulation of the access to genetic resources of natural and historical value and sharing the benefits of their utilisation to favour conservation efforts [PDF]

, 2017
All living organisms contain or produce structures, genetic material and other chemicals that could be potentially useful to humans in various sectors.
4th International Congress on Biodiversity. “Man, Natural Habitats and Euro-Mediterranean Biodiversity”, Fresta, Louis   +1 more
core  

Lessons learned from screening potential other effective area‐based conservation measures

Conservation Biology, EarlyView.
Abstract Other effective area‐based conservation measures (OECMs) are sites that deliver effective biodiversity outcomes irrespective of their management objectives. These areas are widely expected to play an important role in efforts to protect 30% of Earth by 2030.
Carly N. Cook, Madhu Rao, Peter J. Clyne, Vanessa Rathbone, Christian Barrientos, Antonio Boveda, Alex Diment, Jorge Parra, Valeria Falabella, Matthew Linke, Deo Kujirakwinja, Stephane Ostrowski, Kirk Olson, Vardhan Patankar, Lovy Rasolofomanan, Hedley S. Grantham   +15 more
wiley   +1 more source

A call to action: Advancing Indigenous health through the United Nations Convention on Biological Diversity

First Nations Health and Wellbeing - The Lowitja Journal
Indigenous Peoples must be recognised as leaders in planetary health governance at the highest levels. Indigenous Peoples are long standing custodians of nature, live on principles of interconnection with the natural world, and face disproportionate ...
Geoffrey Scott Roth, Alejandro Bermudez del Villar, Liz Willetts   +2 more
doaj   +1 more source

Geneva rhetoric, national reality: implementing TRIPS obligations in Kenya [PDF]

, 2008
The article is about implementing obligations to article 27.3(b) of the Agreement on Trade Related Aspects of Intellectual Property. Using Kenya as a case study, the article seeks to explore how the latitude and space available in article 27.3(b) has ...
Rangnekar, Dwijen
core  

Representativeness of the Natura 2000 network for preserving plant biodiversity in the European Union

Conservation Biology, EarlyView.
Abstract The Natura 2000 (N2K) network of protected areas is one of the main tools for area‐based conservation in the European Union (EU), yet its role in preserving plant biodiversity requires better understanding. We examined data kept in the European Vegetation Archive from over 1.2 million vegetation plots and obtained over 14.2 million plant ...
Michele Di Musciano, Piero Zannini, Riccardo Testolin, Francesco Maria Sabatini, Diletta Santovito, Borja Jiménez‐Alfaro, Florian Jansen, Milan Chytrý, Lorenzo Ricci, Emiliano Agrillo, Fabio Attorre, Idoia Biurrun, Gianmaria Bonari, Hans Henrik Bruun, Luigi Cao Pinna, Andraž Čarni, Maria Laura Carranza, Roberto Cazzolla Gatti, Jürgen Dengler, Michele De Sanctis, Úna Fitzpatrick, Anna Rita Frattaroli, Emmanuel Garbolino, Stephan Hennekens, Ute Jandt, Jan Jansen, Zygmunt Kacki, Ilona Knollová, Jonathan Lenoir, Jesper Erenskjold Moeslund, Tomáš Peterka, Nataša Pipenbaher, Duccio Rocchini, Eszter Ruprecht, Solvita Rūsiņa, Urban Šilc, Sonja Škornik, Grzegorz Swacha, Milan Valachovič, Kiril Vassilev, Wolfgang Willner, Alessandro Chiarucci   +41 more
wiley   +1 more source