Results 91 to 100 of about 10,055,667 (345)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Influence of Type of Management and Climatic Conditions on Productive Behavior, Oenological Potential, and Soil Characteristics of a ‘Cabernet Sauvignon’ Vineyard

open access: yesAgronomy, 2019
(1) Background: Degradation of soils and erosion have been described for most of the soils presented along the Maule Valley. Organic and integrated management promotes agroecosystem health, improving soil biological activity. Due to this, the aim of this
Gastón Gutiérrez-Gamboa   +2 more
doaj   +1 more source

Non-conventional cosmology from a brane-universe

open access: yes, 1999
We consider ``brane-universes'', where matter is confined to four-dimensional hypersurfaces (three-branes) whereas one extra compact dimension is felt by gravity only.
Antoniadis   +13 more
core   +1 more source

Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies

open access: yesInternational Journal of Environmental Research and Public Health, 2020
Triple-negative breast cancer (TNBC) cells are deficient in estrogen, progesterone and ERBB2 receptor expression, presenting a particularly challenging therapeutic target due to their highly invasive nature and relatively low response to therapeutics ...
Mauricio A Medina   +6 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Comparison of CAD/CAM and conventional surgical splints in accuracy of orthognathic surgical planning – a systematic review and meta-analysis

open access: yesClinical and Investigative Orthodontics
Objective The objective of this systematic review was to evaluate the accuracy between CAD/CAM and conventional splints.Search methods/Selection criteria Online databases (PubMed, Dental and Oral Science, CINAHL, Cochrane Central Register of Controlled ...
Afeefa Abul Barakaat   +4 more
doaj   +1 more source

Crop yields and supply of nitrogen compared in conventional and organic farming systems

open access: yesAgricultural and Food Science, 2014
The aim of organic agriculture is to produce food of high nutritional quality in sufficient quantity. Field experiments were conducted to evaluate the effect of organic and conventional growing systems on (i) total amounts and supply of N taken up or ...
Maarika Alaru   +6 more
doaj   +1 more source

An alternative to the conventional micro-canonical ensemble

open access: yes, 2010
Usual approach to the foundations of quantum statistical physics is based on conventional micro-canonical ensemble as a starting point for deriving Boltzmann-Gibbs (BG) equilibrium.
Bender C M   +3 more
core   +1 more source

Wrong by Convention [PDF]

open access: yesEthics, 2017
Some acts (mala in se) are wrong prior to any social prohibition (e.g., murder). Other acts (mala prohibita) are wrong only once socially prohibited (e.g., traffic violations). This article considers certain obligations of care that parents owe to their children and children to their parents.
openaire   +2 more sources

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