Results 131 to 140 of about 10,055,667 (345)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Challenging conventional wisdom with vigour [PDF]

, 2016
Bhandari, Dan G. O'Neill, Darwin, Dawkins, Leroy, Nicholas, Shermer, Stough, Troyer   +8 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Perception of Medical Students on Structured Viva Examination in an Integrated Undergraduate Curriculum at Ziauddin University

Journal of the Dow University of Health Sciences, 2010
Introduction: Exponential growth ofknowledge in the biomedical field has forced the medical educatorsfor a change from traditional to integrated curriculum and conventional assessment techniques to newerstructured techniques.
Anila Jaleel, Noreen Jaffrey
doaj  

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Estimation of Chemical Compounds in Selected Italian and French Wines Produced through Organic and Conventional Methods

Applied Sciences
In this study, Italian and French wines produced through organic and conventional methods were analyzed. Three different varieties of wines were examined, including Cabernet Sauvignon, Merlot, and Syrah.
Alicja Ponder, Maciej Frąckowiak, Marcin Kruk, Ewelina Hallmann   +3 more
doaj   +1 more source

Clues About Bluffing in Clue: Is Conventional Wisdom Wise?

, 2019
We have used the board game Clue as a pedagogical tool in our course on Artificial Intelligence to teach formal logic through the development of logic-based computational game-playing agents.
Hansen, David, Hansen, Kyle D.
core  

Intensive versus conventional glucose control in critically ill patients.

New England Journal of Medicine, 2009
S. Finfer, D. Chittock, Steve Su, D. Blair, D. Foster, V. Dhingra, R. Bellomo, D. Cook, P. Dodek, W. Henderson, P. Hebert, S. Heritier, D. Heyland, C. McArthur, E. McDonald, I. Mitchell, J. Myburgh, R. Norton, Julie Potter, Bruce G. Robinson, J. Ronco   +20 more
semanticscholar   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source