Results 41 to 50 of about 4,048 (131)

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Rapamycin exerts multifaceted immunomodulatory effects in age‐induced atherosclerosis, with pronounced inhibitory effects on adaptive immunity. Rapamycin reduced plaque inflammation and macrophage content, diminished pro‐inflammatory T cell responses, lowered age‐associated B cell frequencies, and attenuated senescence‐associated immune signatures ...
Jill de Mol, Daphne H. de Korte, Marie A. C. Depuydt, Virginia Smit, Mireia N. A. Bernabé Kleijn, Peter J. van Santbrink, Christoph J. Binder, Florentina Porsch, Frank H. Schaftenaar, Amanda C. Foks   +9 more
wiley   +1 more source

Circulating Serum AGRN and ADAMTS8 With Related Candidates as Potential Biomarkers for Carotid Plaque Presence and Vulnerability

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This study investigated serum AGRN and ADAMTS8 as biomarkers for carotid plaques within human participants. Results showed a significant correlation with plaque presence, yielding a moderate combined diagnostic performance. However, these markers poorly differentiated plaque vulnerability.
Shuaiwei Guo, Shengyan Cui, Xiao Zhang, Zixuan Xing, Yixin Sun, Mingqian Qin, Xiaoying Ma, Xiangyu Li, Yan Ma, Peng Gao, Yanfei Chen, Yabing Wang, Bin Yang, Jian Chen, Fei Chen, Xia Lu, Jiaqi Jin, Liqun Jiao, Tao Wang   +18 more
wiley   +1 more source

High Mini-Skin Incision during Carotid Endarterectomy for Carotid Stenosis

Journal of Chest Surgery, 2022
Background: Carotid endarterectomy (CEA) is used to treat carotid stenosis, which is associated with cerebral infarction and may result in neurologic deficits such as stroke, transient ischemic attack (TIA), and local nerve injury.
Byeng Hun Jeon, Chul Ho Lee, Jae Seok Jang, Jun Woo Cho   +3 more
doaj   +1 more source

Diagnosis and Management of Polycythemia Vera Complicated by Cerebral Infarction and Subdural Hematoma: A Case Report

iLABMED, Volume 4, Issue 3, Page 197-203, September 2026.
A 70‐year‐old man with recurrent cerebral infarctions, a subdural hematoma, and atherosclerotic disease involving multiple extracranial vascular territories was subsequently diagnosed with polycythemia vera (PV). In patients with recurrent cerebrovascular events accompanied by otherwise unexplained persistent erythrocytosis, JAK2 mutation testing and ...
Hui Zhao, Jie Feng, Yu Jing, Wei Xie, Yingjiao Sha, Yanhong Gao   +5 more
wiley   +1 more source

Angioscopy Visualized a Residual Free‐Floating Thrombus in Mild Carotid Artery Stenosis Following Acute MCA Occlusion: A Case Report

Catheterization and Cardiovascular Interventions, Volume 108, Issue 1, Page 1-5, July 1, 2026.
ABSTRACT Carotid free‐floating thrombus (CFFT) is a rare yet severe cause of the ischemic stroke. Early identification and appropriate management are crucial to prevent recurrent embolic events. A 76‐year‐old man experienced sudden left‐sided hemiparesis and dysarthria.
Hirofumi Matsubara, Yusuke Egashira, Yukiko Enomoto, Tsuyoshi Izumo   +3 more
wiley   +1 more source

Interplay of Probe Stability and Oscillation During Very‐High‐Power Short‐Duration Ablation in Pulmonary Vein Isolation for Atrial Fibrillation

Pacing and Clinical Electrophysiology, Volume 49, Issue 7, Page 988-999, July 2026.
This graphical abstract presents a comprehensive analysis of probe stability and oscillation during very high‐power short‐duration (vHPSD) pulmonary vein isolation (PVI) for atrial fibrillation. The findings indicate that oscillation velocity serves as a more reliable predictor of impedance drop and temperature changes than contact force alone ...
Ernesto Cristiano, Eduardo Celentano, Barbara Ignatiuk, Martina Renda, Elena Bia, Raffaele Rainone, Jacopo Viganò, Natasja M. S. De Groot   +7 more
wiley   +1 more source

Histopathologic evidence of intimal hyperplasia in carotid artery webs associated with stroke

Free Neuropathology
Background: Carotid artery webs (CWs) are an underrecognized cause of ischemic stroke, particularly in younger patients who lack conventional vascular risk factors.
Farhan Khan, Alisa Nobee, Skylar Lewis, John E. Donahue, Shadi Yaghi   +4 more
doaj   +1 more source

Atherectomy With Multimodal Embolic Protection for Severely Calcified Femoropopliteal Lesions

Catheterization and Cardiovascular Interventions, Volume 107, Issue 5, Page 1350-1354, April 1, 2026.
ABSTRACT Severe calcification in femoropopliteal lesions remains a clinical challenge to achieve both the technical and long‐term success in endovascular therapy. Although atherectomy is an effective treatment for calcified lesions, it is associated with the risk of distal embolization, even with the use of embolic protection devices (EPDs), and ...
Daichi Yoshii, Osamu Iida, Taku Toyoshima, Yoshiteru Okina   +3 more
wiley   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

An oral glucose tolerance test in pregnancy and its association with future cardiovascular diseases

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3146-3154, April 2026.
Abstract Aims/hypothesis Gestational diabetes and abnormal 100‐g oral glucose tolerance test (OGTT) results in pregnancy are associated with type 2 diabetes, but their relationship with cardiovascular disease (CVD) is less clear. We evaluated the risk of CVD according to the number of abnormal OGTT values during pregnancy.
Tal Schiller, Linoy Gabay, Oren Barak, Alena Kirzhner, Haitham Abu Khadija, Gabriel Chodick, Edi Vaisbuch, Yael Barer   +7 more
wiley   +1 more source