Results 131 to 140 of about 59,449 (283)

Graph Neural Network‐Based Multi‐Scale Whole Slide Image Fusion for pT Staging of Muscle‐Invasive Bladder Cancer

Cancer Science, EarlyView.
Accurate pT staging in muscle‐invasive bladder cancer is essential for treatment and prognosis, but current methods rely on time‐consuming and variable microscopic evaluation. We developed a graph neural network–based model that integrates multi‐scale whole‐slide images to automate pT staging, achieving excellent performance with an AUC of 0.911 and ...
Qian Li, Qing Feng Chen, Nan Qing Liao
wiley   +1 more source

Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. [PDF]

, 1997
We have analyzed the progressive changes in the spatial distribution of telomeres during meiosis using three-dimensional, high resolution fluorescence microscopy.
Agard, DA, Bass, HW, Cande, WZ, Marshall, WF, Sedat, JW   +4 more
core  

Urinary Tumor DNA to Identify Candidates for Repeat Transurethral Resection in Non‐Muscle‐Invasive Bladder Cancer

Cancer Science, EarlyView.
Urinary tumor DNA (utDNA) represents a powerful noninvasive biomarker to refine the need for repeat TURBT in high‐risk NMIBC. In our cohort of 161 patients, utDNA testing achieved superior accuracy to cytology, strongly predicted residual disease and recurrence, and could safely reduce unnecessary repeat resections by up to one‐third.
Zihan Xue, Yunkai Qie, Chong Shen, Zhouliang Wu, Houyuan Chen, Yuda Lin, Rongjiang Li, Shiwang Huang, Hailong Hu   +8 more
wiley   +1 more source

Impact of Sequential Ramucirumab Plus Docetaxel After PD‐1 Inhibitors on Anti‐PD‐1 Antibody‐Bound T‐Cell Dynamics and Clinical Outcomes

Cancer Science, EarlyView.
Ramucirumab (RAM) plus docetaxel (DOC) after PD‐1 inhibitors showed clinical activity, with responders exhibiting maintained anti–PD‐1 (IgG4+)‐bound CD8+ T cells and decreased IgG4+ Tregs. A sequential strategy of administering RAM plus DOC during persistent anti–PD‐1 antibody binding may be beneficial in patients with advanced non‐small cell lung ...
Kinnosuke Matsumoto, Yujiro Naito, Takayuki Shiroyama, Motohiro Tamiya, Kazumi Nishino, Akihiro Tamiya, Kyoichi Okishio, Yuhei Kinehara, Tomoki Kuge, Masahide Mori, Shingo Satoh, Hidekazu Suzuki, Satoshi Tetsumoto, Toshie Niki, Yasuhiko Suga, Akio Osa, Toshiyuki Minami, Shohei Koyama, Yoshito Takeda, Nobuyuki Takakura, Atsushi Kumanogoh   +20 more
wiley   +1 more source

Randomised trial of assessing diagnostic yield in transbronchial biopsy with a guide sheath

ERJ Open Research
Objectives Radial probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) with a guide sheath (GS) is widely used to diagnose peripheral lung lesions (PPLs), but there is no consensus on whether it increases the diagnostic yield.
Hao-Chun Chang, Yao-Wen Kuo, Ching-Kai Lin, Lih-Chyun Chang, You-Yi Chen, Ching-Yao Yang, Jung-Yien Chien, Chia-Lin Hsu, Tzu-Hsiu Tsai, Chao-Chi Ho, Jin-Yuan Shih, Chong-Jen Yu   +11 more
doaj   +1 more source

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

Comparative study of conventional exfoliative cytology and centrifuged liquid-based cytology in oral leukoplakia and oral squamous cell carcinoma patients

Dental Research Journal
Background: This study aims to compare the efficacy between conventional exfoliative cytology (EC) and centrifuged liquid-based cytology (CLBC) in control, leukoplakia, and oral squamous cell carcinoma (OSCC) patients.
R. Jayabalan, Ambika Murugesan, Sekar Balakrishnan, Maya Ramesh   +3 more
doaj   +1 more source

Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis

Equine Veterinary Education, EarlyView.
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch, C. Frank, J. B. Daniels, E. Acutt, E. Contino   +4 more
wiley   +1 more source

Improving mare fertility via broad ligament imbrication with barbed suture and intracorporeal suturing device

Equine Veterinary Education, EarlyView.
Summary In this short case series, we report the outcome of four mares undergoing mesometrial imbrication (uteropexy) using barbed suture and an automated laparoscopic suturing device. Medical records of four mares infertile because of delayed uterine clearance (DUC) that underwent laparoscopic mesometrial imbrication to elevate a vertically positioned
A. del Rincon, J. M. O'Leary, A. Derham, C. Hawkes   +3 more
wiley   +1 more source

Primary cardiac T‐cell rich large B‐cell lymphoma causing aortic stenosis with metastasis in a Warmblood

Equine Veterinary Education, EarlyView.
Summary An 18‐year‐old Warmblood mare was presented to the Royal Veterinary College Equine Referral Hospital for investigation of progressive periocular and facial swelling, weight loss and tachycardia. Physical examination additionally identified bilateral pansystolic (grade 5/6 basilar left‐sided, 2/6 right‐sided), cardiac murmurs, submandibular ...
S. E. Talbot, F. Z. X. Lean, H. M. Martineau, B. Dunkel, J. Reed   +4 more
wiley   +1 more source