Results 71 to 80 of about 59,449 (283)

A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples [PDF]

, 2016
Paper diagnostics have successfully been employed to detect the presence of antigens or small molecules in clinical samples through immunoassays; however, the detection of many disease targets relies on the much higher sensitivity and specificity ...
Dewar, Rajan, Klapperich, Catherine, Liu, Lena, Rodriguez, Natalia Maria, Wong, Winnie S.   +4 more
core   +2 more sources

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

Prospective Feasibility Study of Laparoscopic and Robotic Distal Gastrectomy for Advanced Gastric Cancer to Verify the Safety of Surgical Proximal Margins

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Ensuring an adequate surgical proximal margin (SPM) is crucial in radical gastrectomy for gastric cancer. However, the lack of tactile feedback in laparoscopic distal gastrectomy (LDG) and robotic distal gastrectomy (RDG) poses challenges in precisely determining tumor boundaries, particularly in advanced gastric cancer, where tumor ...
Rie Makuuchi, Souya Nunobe, Naoki Ishizuka, Shinichiro Atsumi, Yoshiaki Shoji, Motonari Ri, Masaru Hayami, Tomoyuki Irino, Manabu Ohashi, Takeshi Sano   +9 more
wiley   +1 more source

Histology Combined with Cytology by Endoscopic Ultrasound-Guided Fine Needle Aspiration for the Diagnosis of Solid Pancreatic Mass and Intra-Abdominal Lymphadenopathy

Gut and Liver, 2013
Background/AimsSmall core biopsy samples can occasionally be obtained with conventional endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA).
doaj   +1 more source

Deep Learning‐Assisted Coherent Raman Scattering Microscopy

Advanced Intelligent Discovery, EarlyView.
The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu, Rujia Liu, Xinyan Zhang, Xun Chen, Shuhua Yue   +4 more
wiley   +1 more source

Use of HPV testing in cervical cancer screening services in Mexico, 2008-2018: a nationwide database study

Salud Pública de México, 2018
Objective. To describe the methods of a study aimed at evaluating high risk-HPV (hrHPV)-based screening and cervical cytology as triage compared to conventional cervi­cal cytology as primary screening in the detection of grade 2+ cervical intraepithelial
Erika Hurtado-Salgado, Eduardo Ortiz-Panozo, Jorge Salmerón, Nenetzen Saavedra-Lara, Pablo Kuri-Morales, Eduardo Pesqueira-Villegas, Rufino Luna-Gordillo, Eduardo L Franco, Eduardo Lazcano-Ponce   +8 more
doaj   +1 more source

Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice

Diagnostics, 2020
Background: The diagnosis of lymphoma requires surgical specimens to perform morphological evaluation, immunohistochemical and molecular analyses. Ultrasound-guided fine needle aspiration may represent an appropriate first approach to obtain cytological ...
Paola Parente, Claudia Covelli, Magda Zanelli, Domenico Trombetta, Illuminato Carosi, Cristiano Carbonelli, Marco Sperandeo, Luca Mastracci, Giovanni Biancofiore, Maurizio Zizzo, Marco Taurchini, Stefano Ascani, Paolo Graziano   +12 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Cytomorphological differences between liquid-based cytology and conventional smears in fine-needle aspirates of thyroid lesions

Journal of Cytology, 2018
Background: Liquid-based cytology (LBC) is becoming an independent processing modality for cytology specimens. Decreased obscuration, single-slide examination, lesser screening time, and potential application of ancillary techniques are the various ...
Shuchita Sharma, Shilpi Agarwal, Manjula Jain, Gautam Bir Singh, Manoj Andley   +4 more
doaj   +1 more source

Critical analyses of the introduction of liquid-based cytology in a public health service of the state of São Paulo, Brazil [PDF]

, 2015
OBJECTIVE The aim of this study was to compare the performance of the current conventional Pap smear with liquid-based cytology (LBC) preparations. STUDY DESIGN Women routinely undergoing their cytopathological and histopathological examinations at ...
Cohen, Diane, Cury, Lise, Eluf Neto, José, Levi, José Eduardo, Longatto Filho, Adhemar, Martins, Toni Ricardo, Villa, Luisa Lina   +6 more
core   +1 more source