Results 91 to 100 of about 377,306 (268)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Joint Position Effects on Biceps Femoris and Peroneal Muscle Activation and Ankle Evertor Strength

Physical Therapy Korea
Background: The peroneus longus (PL) and peroneus brevis (PB) function as the primary muscles of eversion, a movement closely associated with tibial external rotation for ankle mor-tise stability.
Do-eun Lee, Jun-hee Kim, Seung-yoon Han, Oh-yun Kwon   +3 more
doaj   +1 more source

Convergence Rate Analysis of LION

CoRR
The LION (evoLved sIgn mOmeNtum) optimizer for deep neural network training was found by Google via program search, with the simple sign update yet showing impressive performance in training large scale networks. Although previous studies have investigated its convergence properties, a comprehensive analysis, especially the convergence rate, is still ...
Yiming Dong, Huan Li 0007, Zhouchen Lin
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Convergence Order of the Reproducing Kernel Method for Solving Boundary Value Problems

Mathematical Modelling and Analysis, 2016
In this paper, convergence rate of the reproducing kernel method for solving boundary value problems is studied. The equivalence of two reproducing kernel spaces and some results of adjoint operator are proved.
Zhihong Zhao, Yingzhen Lin, Jing Niu
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Unified Method for Online Detection of Phase Variables and Symmetrical Components of Unbalanced Three-Phase Systems with Harmonic Distortion

Energies, 2019
This paper presents a method for online detection of symmetrical components of arbitrarily distorted and biased three-phase input signals. This method is based on Second-Order Generalized Integrators (SOGIs), for which a new tuning based on a gradient ...
Christoph M. Hackl, Markus Landerer
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative Comparison of Shoulder Muscle Strength and Functional Outcomes in Rotator Cuff Tear Patients

Physical Therapy Korea
Background: Rotator cuff tears often cause shoulder pain and functional limitations that may require conservative treatment or surgical intervention.
Jin-seong Kim, Ui-jae Hwang, Il-kyu Ahn, Oh-yun Kwon   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source