Results 81 to 90 of about 22,889,224 (309)

Dissemination of pathogenic bacteria is reinforced by a MARTX toxin effector duet

Nature Communications
Multiple bacterial genera take advantage of the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin to invade host cells. Secretion of the MARTX toxin by Vibrio vulnificus, a deadly opportunistic pathogen that causes primary septicemia, the ...
Sanghyeon Choi, Youngjin Lee, Shinhye Park, Song Yee Jang, Jongbin Park, Do Won Oh, Su-Man Kim, Tae-Hwan Kim, Ga Seul Lee, Changyi Cho, Byoung Sik Kim, Donghan Lee, Eun-Hee Kim, Hae-Kap Cheong, Jeong Hee Moon, Ji-Joon Song, Jungwon Hwang, Myung Hee Kim   +17 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Optimization of operating conditions for Gamma Emission Tomography to improve partial-defect detection accuracy within PWR-type spent nuclear fuel

Nuclear Engineering and Technology
The Spent Nuclear Fuel (SNF) contains a variety of nuclear material that can be diverted for military purposes and unauthorized proliferation. To ensure safety management and non-proliferation of SNF, an effective inspection method, such as Gamma ...
Hyung-Joo Choi, Hyun Joon Choi, Hyun Cheol Lee, Yong Hyun Chung, Chul Hee Min   +4 more
doaj   +1 more source

Convergence Rate Analysis of LION

CoRR
The LION (evoLved sIgn mOmeNtum) optimizer for deep neural network training was found by Google via program search, with the simple sign update yet showing impressive performance in training large scale networks. Although previous studies have investigated its convergence properties, a comprehensive analysis, especially the convergence rate, is still ...
Yiming Dong, Huan Li 0007, Zhouchen Lin
openaire   +2 more sources

Convergence and tracking analysis of the ε-NSRLMF algorithm

, 2013
In this work, the convergence and tracking behavior of the ε-normalized sign regressor least mean fourth (NSRLMF) algorithm are analyzed in the presence of white and correlated Gaussian data.
Zerguine, A., Ulla Faiz, M.
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Sectoral Energy- and Labour-Productivity Convergence [PDF]

This paper provides an empirical analysis of energy- and labour-productivity convergence at a detailed sectoral level for 14 OECD countries, covering the period 1970-1997.
Henri De Groot, Peter Mulder
core   +2 more sources

Privacy-Preserving Energy Scheduling for Smart Grid With Renewables

IEEE Access, 2020
We consider joint demand response and power procurement to optimize the average social welfare of a smart power grid system with renewable sources. The renewable sources such as wind and solar energy are intermittent and fluctuate rapidly.
Kai Yang, Libin Jiang, Steven H. Low, Sijia Liu   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Health expenditure trajectory and gastric cancer incidence in the National Health Insurance Senior Cohort: a nested case-control study

BMC Health Services Research
Background Gastric cancer is the fourth most common cancer and highly prevalent in South Korea. As one of the predictors of gastric cancer, we focused on health utilization patterns and expenditures, as the surrogate variables of health conditions.
Woo-Ri Lee, Ki-Bong Yoo, Jin-Won Noh, Minjee Lee   +3 more
doaj   +1 more source