Results 61 to 70 of about 22,889,224 (309)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

REAL CONVERGENCE VERSUS NOMINAL CONVERGENCE - A COMPARATIVE ANALYSIS [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2012
The main purpose of this study is to quantify and analyze the gap between the developmentregions of Romania through formulas that reveal the existence or not of the convergence types.The statistical data were obtained from the National Institute of ...
Ceausescu Ionut
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Habitual Cross-legged Sitting Increases Lumbopelvic Rotation Asymmetry

Physical Therapy Korea
Background: Cross-legged sitting posture (CLSP) is common in daily life but may cause asymmetrical loading of the pelvis and spine, potentially leading to postural imbalance and musculoskeletal problems.
Han Seung-yoon, Gwak Gyeong-tae, Yoo Hwa-ik, Ahn Il-kyu, Kwon Oh-yun   +4 more
doaj   +1 more source

Finite Element Analysis and Electrohydrodynamic Multiphysics Modeling of a Corona-Streamer Discharge in a Two-Phase Flow Medium

Energies
This study proposes an electrohydrodynamic multiphysics modeling and finite element analysis technique to accurately simulate corona-streamer discharges in a two-phase flow medium.
Myung-Ki Baek, Ho-Young Lee
doaj   +1 more source

Convergence Properties of an Extended Least Squares (ELS) Variant [PDF]

Modeling, Identification and Control, 2000
By factorizing the A- and B-polynomials in an ARMAX model and filtering the input/output data with the appropriate factors thereof, the parameters of the model can be estimated in a decentralized fashion.
Rolf Henriksen
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comparison of the Pelvic Rotation Angle During Hip Lateral Rotation in the Standing and Prone Positions in Participants With and Without Tensor Fasciae Latae/Iliotibial Tract Tightness

Physical Therapy Korea
Background: Tensor fasciae latae (TFL) and iliotibial tract (ITB) tightness can pull the pelvis during hip lateral rotation (HLR), increasing pelvic rotation due to muscle tension.
Baek Ha-yeong, Ahn Il-kyu, Gwak Gyeong-tae, Kwon Oh-yun   +3 more
doaj   +1 more source