Results 51 to 60 of about 22,889,224 (309)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Convergence Analysis of a Numerical Method for a Structured Consumer-Resource Model with Delay in the Resource Evolution Rate

Mathematics, 2020
In this paper, we go through the development of a new numerical method to obtain the solution to a size-structured population model that describes the evolution of a consumer feeding on a dynamical resource that reacts to the environment with a lag-time ...
Luis M. Abia, Óscar Angulo, Juan C. López-Marcos, Miguel A. López-Marcos   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Chromosome level de Novo hybrid assembly of Asian honeybee, Apis cerana Koreana

Scientific Reports
Apis cerana is a vital pollinator in East Asia and a model species for studying eusociality, which includes complex group decision-making and specialized task systems. However, the population of Apis cerana is facing a significant decline globally due to
Jeong-Hyeon Lee, Byung-Ju Kim, Giyoun Han, Olga Frunze, Gyongju Nah, Hyung Wook Kwon   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Enhancing bonding strength of the electroplated Cu pillars for semiconductor package by controlling grain orientation

Scientific Reports
The Cu pillar bump, an electrode formed on a silicon chip, connects the devices inside a high bandwidth memory (HBM) package and is the most important interconnection affecting the electrical, thermal, and mechanical properties of advanced semiconductor ...
JaeJun Yoon, TaekSoo Shin, DongJin Kim, KunSang Park, DongKeun Na, Yeonju Go, SeungBoo Jung   +6 more
doaj   +1 more source

A General Analysis of the Convergence of ADMM

CoRR, 2015
We provide a new proof of the linear convergence of the alternating direction method of multipliers (ADMM) when one of the objective terms is strongly convex. Our proof is based on a framework for analyzing optimization algorithms introduced in Lessard et al. (2014), reducing algorithm convergence to verifying the stability of a dynamical system.
Robert Nishihara, Laurent Lessard, Benjamin Recht, Andrew K. Packard, Michael I. Jordan   +4 more
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An Analysis of the Convergence of Graph Laplacians

, 2011
Existing approaches to analyzing the asymptotics of graph Laplacians typically assume a well-behaved kernel function with smoothness assumptions. We remove the smoothness assumption and generalize the analysis of graph Laplacians to include previously unstudied graphs including kNN graphs.
Daniel Ting, Ling Huang 0001, Michael I. Jordan   +2 more
openaire   +3 more sources

Convergence analysis of an Inexact Infeasible Interior Point method for Semidefinite Programming [PDF]

, 2004
In this paper we present an extension to SDP of the well known infeasible Interior Point method for linear programming of Kojima,Megiddo and Mizuno (A primal-dual infeasible-interior-point algorithm for Linear Programming, Math. Progr., 1993).
Pieraccini, Sandra, Bellavia, S
core   +1 more source