Results 41 to 50 of about 23,966,298 (311)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Convergence analysis of the epsilon NSRLMMN algorithm
, 2012 In this work, the ε-normalized sign regressor least mean mixed-norm (NSRLMMN) adaptive algorithm is proposed. The proposed algorithm exhibits increased convergence rate as compared to the least mean mixed-norm (LMMN) and the sign regressor least mean ...
Zerguine, A., Ulla Faiz, M.
core +1 more source
Chromosome level de Novo hybrid assembly of Asian honeybee, Apis cerana Koreana
Scientific ReportsApis cerana is a vital pollinator in East Asia and a model species for studying eusociality, which includes complex group decision-making and specialized task systems. However, the population of Apis cerana is facing a significant decline globally due to
Jeong-Hyeon Lee +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Scientific ReportsThe Cu pillar bump, an electrode formed on a silicon chip, connects the devices inside a high bandwidth memory (HBM) package and is the most important interconnection affecting the electrical, thermal, and mechanical properties of advanced semiconductor ...
JaeJun Yoon +6 more
doaj +1 more source
Non-Convex Split Feasibility Problems: Models, Algorithms and Theory
Open Journal of Mathematical Optimization, 2020 In this paper, we propose a catalog of iterative methods for solving the Split Feasibility Problem in the non-convex setting. We study four different optimization formulations of the problem, where each model has advantages in different settings of the ...
Gibali, Aviv +2 more
doaj +1 more source
A Multi-Step Inertial Proximal Peaceman-Rachford Splitting Method for Separable Convex Programming
IEEE Access, 2023 In this paper, we propose a multi-step inertial proximal Peaceman-Rachford splitting method (abbreviated as MIP-PRSM) for solving the two-block separable convex optimization problems with linear constraints, which is a unified framework for such Peaceman-
Hongyan Li, Dongmei Yu, Leifu Gao
doaj +1 more source
On the Convergence Analysis of the Optimized Gradient Method. [PDF]
J Optim Theory Appl, 2017 This paper considers the problem of unconstrained minimization of smooth convex functions having Lipschitz continuous gradients with known Lipschitz constant. We recently proposed an optimized gradient method (OGM) for this problem and showed that it has a worst-case convergence bound for the cost function decrease that is twice as small as that of ...
Kim D, Fessler JA.
europepmc +6 more sources
A General Analysis of the Convergence of ADMM
CoRR, 2015 We provide a new proof of the linear convergence of the alternating direction method of multipliers (ADMM) when one of the objective terms is strongly convex. Our proof is based on a framework for analyzing optimization algorithms introduced in Lessard et al. (2014), reducing algorithm convergence to verifying the stability of a dynamical system.
Robert Nishihara +4 more
openaire +4 more sources