Results 51 to 60 of about 1,976,299 (274)

Convergence Analysis of Leapfrog for Geodesics

SIAM Journal on Numerical Analysis, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Erchuan Zhang, Lyle Noakes
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Some new numerical schemes for finding the solutions to nonlinear equations

AIMS Mathematics, 2022
We introduce a sequence of third and fourth-order iterative schemes for finding the roots of nonlinear equations by using the decomposition technique and Simpson's one-third rule.
Awais Gul Khan, Farah Ameen, Muhammad Uzair Awan, Kamsing Nonlaopon   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Finite Element Analysis and Electrohydrodynamic Multiphysics Modeling of a Corona-Streamer Discharge in a Two-Phase Flow Medium

Energies
This study proposes an electrohydrodynamic multiphysics modeling and finite element analysis technique to accurately simulate corona-streamer discharges in a two-phase flow medium.
Myung-Ki Baek, Ho-Young Lee
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Habitual Cross-legged Sitting Increases Lumbopelvic Rotation Asymmetry

Physical Therapy Korea
Background: Cross-legged sitting posture (CLSP) is common in daily life but may cause asymmetrical loading of the pelvis and spine, potentially leading to postural imbalance and musculoskeletal problems.
Han Seung-yoon, Gwak Gyeong-tae, Yoo Hwa-ik, Ahn Il-kyu, Kwon Oh-yun   +4 more
doaj   +1 more source

Convergence Properties of an Extended Least Squares (ELS) Variant [PDF]

Modeling, Identification and Control, 2000
By factorizing the A- and B-polynomials in an ARMAX model and filtering the input/output data with the appropriate factors thereof, the parameters of the model can be estimated in a decentralized fashion.
Rolf Henriksen
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Convergence Analysis of Mean Shift

IEEE Transactions on Pattern Analysis and Machine Intelligence
18 pages, 2 figures, preprint ...
Ryoya Yamasaki, Toshiyuki Tanaka
openaire   +3 more sources