Results 61 to 70 of about 256,571 (266)

The distribution of Dishevelled in convergently extending mesoderm [PDF]

Developmental Biology, 2013
Convergent extension (CE) is a conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity (PCP) pathway. In Drosophila epithelia, a polarised subcellular accumulation of PCP core components, such as Dishevelled (Dvl) protein, is associated with PCP function.
Panousopoulou, Eleni, Tyson, Richard A, Bretschneider , Till, Green, Jeremy B.A.   +3 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Statistical analysis of the results of real dice rolls using the object detection model in the context of the Central Limit Theorem

Journal of Computer Sciences Institute
The study conducted an analysis of the convergence of the distribution of sums of real dice-roll results toward the normal distribution in the context of the Central Limit Theorem.
Kacper Gębusia, Edyta Łukasik
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

A generalization of the global limit theorems of R. P. Agnew

International Journal of Mathematics and Mathematical Sciences, 1988
For distribution functions {Fn,n≥0}, the relationship between the weak convergence of Fn to F0 and the convergence of ∫Rϕ(|Fn−F0|)dx to 0 is studied where ϕ is a nonnegative, nondecreasing function.
Andrew Rosalsky
doaj   +1 more source

Convergence Analysis of Economic Growth in East Java

JEJAK: Jurnal Ekonomi dan Kebijakan, 2018
Convergence and divergence of economic growth is a regional economic issue. The concept of convergence occurs when areas with poor economies tend to grow faster than areas with a rich economy whereas divergence occurs otherwise.
Sri Karima Amalia, Dwi Budi Santoso, Sasongko Sasongko   +2 more
doaj   +1 more source

Convergence Speed in Distributed Consensus and Averaging [PDF]

SIAM Journal on Control and Optimization, 2009
We study the convergence speed of distributed iterative algorithms for the consensus and averaging problems, with emphasis on the latter. We first consider the case of a fixed communication topology. We show that a simple adaptation of a consensus algorithm leads to an averaging algorithm.
Olshevsky, Alexander, Tsitsiklis, John N.   +1 more
openaire   +4 more sources

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

On the Convergence of Empiric Distribution Functions

The Annals of Mathematical Statistics, 1955
Let $\mu$ be a probability measure on the Borel sets of $k$-dimensional Euclidean space $E_k.$ Let ${X_n}, n = 1, 2, \cdots,$ be a sequence of $k$-dimensional independent random vectors, distributed according to $\mu.$ For each $n = 1, 2, \cdots$ let $\mu_n$ be the empiric distribution function corresponding to $X_1, \cdots, X_n,$ i.e., for every Borel
openaire   +2 more sources