Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Several new aspects on q-Horn and related triple functions in the spirit of Karlsson
We first introduce a notation for multiple (n ≥ 3) q-hypergeometric functions, where negative values of summation indices are allowed. Then we extend the notation for q-Horn functions to include tilde values corresponding to powers of 2.
Ernst Thomas
doaj +1 more source
Convergência da Produtividade Agropecuária do Sul do Brasil: uma análise espacial
Resumo: Este trabalho tem como objetivo analisar a evolução da produtividade da agropecuária nas microrregiões do Sul do Brasil, identificando a existência de um processo de convergência. Para isso, mensurou-se a produtividade da agropecuária em 1995/96
Augusta Pelinski Raiher +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Convergence through Regionalization
In the process of European integration, structural convergence has progressively become a central objective of the community policies. Thus, the convergence requirement follows from sharpening the differences between member countries and their regions, due both to the functioning of the four freedoms and to the successive expansions towards countries ...
Mihaela NECULITA, Daniela Ancuta SARPE
openaire +2 more sources
Extended convergence of two-step iterative methods for solving equations with applications
The convergence of two-step iterative methods of third and fourth order of convergence are studied under weaker hypotheses than in earlier works using our new idea of the restricted convergence region.
Ioannis K. Argyros, Santhosh George
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Processy konvergencii i divergencii v regionah Evropejskogo sojuza: osobennosti i kvalimetrija [Processes of convergence and divergence in the re-gions of the European Union: features and qualimetry] [PDF]
A higher level of unity and cohesion across the European Union member states is an important aspect of European integration though it has a rather ambiguous nature.
Voronov Viktor, Lavrinenko Olga
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source

