Results 41 to 50 of about 224,580 (266)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Regional cohesion: evidence and theories of regional growth and convergence [PDF]

European Economic Review, 1996
Abstract After arguing that the concepts of β-convergence and σ-convergence are independently interesting, this paper extends the empirical evidence on regional growth and convergence across the United States, Japan, and five European nations. We confirm that the estimated speeds of convergence are surprisingly similar across data sets: regions tend ...
openaire   +4 more sources

STUDY ON THE CAUSES OF REGIONAL ECONOMIC DISPARITIES IN ROMANIA [PDF]

Annals of the University of Oradea: Economic Science, 2011
Successive enlargements of the European Union have led to increasing heterogeneity of the development levels of the states and regions members. The Romanian development regions are among the most poorly economically developed European regions and are ...
Borza Mioara, Mihai Talmaciu
doaj  

Processes of convergence and divergence in the regions of the European Union: features and qualimetry [PDF]

Baltic Region, 2013
A higher level of unity and cohesion across the European Union member states is an important aspect of European integration though it has a rather ambiguous nature.
Voronov Viktor, Lavrinenko Olga
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Regional Convergence of Fertility in Russia

Economy of Region, 2019
The balance of the regions’ demographic dynamics in many ways determines the country’s sustainable demographic development. The high level of the regional fertility differentiation, historically manifested in Russia, requires the development of specific tools.
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Zonal Migration of Monsoon Moisture Flux Convergence and the Strength of Madden‐Julian Oscillation Events

Geophysical Research Letters, 2019
Understanding the variations in the strength of Madden‐Julian Oscillation (MJO) events as they propagate across the Indo‐Pacific Maritime Continent has been an unmet challenge.
Samson Hagos, Chidong Zhang, L. Ruby Leung, Casey D. Burleyson, Karthik Balaguru   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Regional economic disparities in Colombia [PDF]

Investigaciones Regionales - Journal of Regional Research, 2009
This paper advances the analysis of regional income convergence inColombia, through the use of the income data recently estimated for the departments,the main subnational political units. The results show a polarization process betweenBogotá and the rest
Jaime Bonet, Adolfo Meisel
doaj