Results 61 to 70 of about 228,817 (308)

Regional economic disparities in Colombia [PDF]

open access: yesInvestigaciones Regionales - Journal of Regional Research, 2009
This paper advances the analysis of regional income convergence inColombia, through the use of the income data recently estimated for the departments,the main subnational political units. The results show a polarization process betweenBogotá and the rest
Jaime Bonet, Adolfo Meisel
doaj  

On the convergence of multidimensional S-fractions with independent variables

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2018
In this paper, we investigate the convergence of multidimensional S-fractions with independent variables, which are a multidimensional generalization of S-fractions.
O.S. Bodnar, R.I. Dmytryshyn
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

A modified filter nonmonotone adaptive retrospective trust region method.

open access: yesPLoS ONE, 2021
In this paper, aiming at the unconstrained optimization problem, a new nonmonotone adaptive retrospective trust region line search method is presented, which takes advantages of multidimensional filter technique to increase the acceptance probability of ...
Xianfeng Ding, Quan Qu, Xinyi Wang
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Analysis of convergence process of East German economy on the base of a two-region growth model [PDF]

open access: yes
The main purpose of the paper is to analyse the speed of regional convergence of unified Germany on the basis of a two-region growth model with public productive spending.
Kilin F.S.
core  

Convergence and stability in US regional employment [PDF]

open access: yes, 2002
It is widely believed that regional labour markets in the USA are highly flexible, so that employment shocks have only transitory effects on joblessness since induced migration quickly offsets much of the initial impact. However time-series analysis of the response to shocks is very sensitive to errors of measurement in labour market data, and such ...
Andrew Glyn, Robert Rowthorn
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

SHAP-based interpretable machine learning for injury risk prediction in university football players: a multi-dimensional data analysis approach

open access: yesScientific Reports
Sports injury prediction is crucial for university football player health, yet existing research predominantly focuses on professional athletes and lacks interpretability.
Jiacheng Ma, Shengrui Liu, Yuting Pei
doaj   +1 more source

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