Results 41 to 50 of about 6,349 (218)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

λ-Statistical Convergence in Paranormed Space

Abstract and Applied Analysis, 2013
The concept of λ-statistical convergence for sequences of real numbers was introduced in Mursaleen (2000). In this paper, we prove decomposition theorem for λ-statistical convergence.
Mohammed A. Alghamdi, Mohammad Mursaleen
doaj   +1 more source

A Light‐Stimulus Flexible Synaptic Transistor Based on Ion‐Gel Side‐Gated Graphene for Neuromorphic Computing

Advanced Photonics Research, 2022
Optogenetic technology is to express the channel proteins that can be act on light for realizing the activity of neurons activated and inhibited. Here, inspired by optogenetics, a flexible side‐gate artificial synaptic transistor based on ion gel and ...
Shilin Liu, Xiaoying He, Jiale Su, Bowen Cao, Lan Rao, Chong Li, Xiaohong Yang, Xiangjun Xin   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Kramers–Kronig Transmission with a Crosstalk-Dependent Step Multiple-Input Multiple-Output Volterra Equalizer in a Seven-Core Fiber

Photonics, 2023
In this paper, we experimentally demonstrate a net bit rate of 261.7 Gbit/s in a seven-core transmission system with a Kramers–Kronig (KK) receiver. The 10 GBaud 16-level quadrature amplitude modulation (QAM) signal is transmitted over a 2.5 km seven ...
Feng Tian, Tianze Wu, Chao Yu, Chuxuan Wang, Mohai Yue, Ran Gao, Qi Zhang, Zhipei Li, Qinghua Tian, Fu Wang, Xiangjun Xin   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Review on Mechanical Proving and Formalization of Mathematical Theorems

IEEE Access
The field of artificial intelligence represents a frontier and a focal point of contemporary technological development. As an important embodiment of artificial intelligence applied to theoretical-level research, mechanical proving has been a subject of ...
Si Chen, Wensheng Yu, Guowei Dou, Qimeng Zhang   +3 more
doaj   +1 more source

Three-Step Derivative-Free Method of Order Six

Foundations, 2023
Derivative-free iterative methods are useful to approximate the numerical solutions when the given function lacks explicit derivative information or when the derivatives are too expensive to compute.
Sunil Kumar, Janak Raj Sharma, Ioannis K. Argyros, Samundra Regmi   +3 more
doaj   +1 more source