Results 101 to 110 of about 1,948,990 (331)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

On the Positive Effect of Delay on the Rate of Convergence of a Class of Linear Time-Delayed Systems

open access: yes, 2019
This paper is a comprehensive study of a long observed phenomenon of increase in the stability margin and so the rate of convergence of a class of linear systems due to time delay.
Kia, Solmaz S., Moradian, Hossein
core   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

Engineering wired network performance enhancement in a route redistributed simulation based systems [PDF]

open access: yesBig Data and Computing Visions
As organizations keep expanding every day, there is a rapidly increasing need for communication networks to share routing information amongst the different routing protocols reliably.
Aniekan Ikpe, Imoh Ekanem
doaj   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

open access: yesAging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst   +4 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

On Measuring Convergence in the Use of Time [PDF]

open access: yes
In the study of the effects of retirement on the allocation of time, this paper discusses methods that evaluate convergence in patterns of time use. Scalar measures of multivariate scatter are revealed to be a more general method than previous devices ...
Jorge Gonzalez-Chapela
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Enhancing Precise Point Positioning Under Active Ionosphere Using Wide-Range Ionospheric Corrections Derived from MADOCA Service

open access: yesApplied Sciences
The performance of the MADOCA-PPP (Multi-GNSS Orbit and Clock Augmentation-Precise Point Positioning) wide-range ionospheric correction requires further investigation during periods of high ionospheric activity, particularly regarding its impact on the ...
Qianqian Bian, Xiao Yin
doaj   +1 more source

Spatial reorganization and time-space convergence

open access: yes, 1966
Most scholars in geography and related social sciences have recognized that the locational structure of man's economic, political and cultural activities is not in a static state. Yet, very little attempt has been made to conceptualize the manner by which the spatial arrangement of man's establishments change over time.
openaire   +2 more sources

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