Results 61 to 70 of about 340,729 (265)

Engineering wired network performance enhancement in a route redistributed simulation based systems [PDF]

Big Data and Computing Visions
As organizations keep expanding every day, there is a rapidly increasing need for communication networks to share routing information amongst the different routing protocols reliably.
Aniekan Ikpe, Imoh Ekanem
doaj   +1 more source

Convergence Properties for Discrete-Time Nonlinear Systems [PDF]

IEEE Transactions on Automatic Control, 2019
Three similar convergence notions are considered. Two of them are the long established notions of convergent dynamics and incremental stability. The other is the more recent notion of contraction analysis. All three convergence notions require that all solutions of a system converge to each other.
Duc N. Tran, Bjorn S. Ruffer, Christopher M. Kellett   +2 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Efficient implementation of LMS adaptive filter-based FECG extraction on an FPGA

Healthcare Technology Letters, 2020
In this Letter, the field programmable gate array (FPGA) implementation of a foetal heart rate (FHR) monitoring system is presented. The system comprises a preprocessing unit to remove various types of noise, followed by a foetal electrocardiogram (FECG)
Bhavya Vasudeva, Puneesh Deora, Puneesh Deora, Pradhan Mohan Pradhan, Sudeb Dasgupta, Sudeb Dasgupta   +5 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

INTERIOR GATEWAY PROTOCOL ROUTING PERFORMANCE COMPARISON OF THE VIRTUAL PRIVATE NETWORK BASED ON MULTI PROTOCOL LABEL SWITCHING AND DIRECT-LINK BACKUPSED ON MPLS AND DIRECT-LINK BACKUP

Jurnal Ilmiah SINERGI, 2019
The stability and convergence time become an essential factor in network availability performance. Multiprotocol Label Switching (MPLS) is one of the Virtual Private Network (VPN) technologies that can support the quality of communication media on the ...
Ida Nurhaida, Dimas Widya Putra Pratama, Remmy A. M. Zen, Hong Wei   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

GDP and Convergence in Modern Times [PDF]

, 2014
In this chapter, I discuss historical estimates of GDP at both the national and the regional level and their application for assessing economic performance in modern times. Having been invented in (and conceived for) industrial capitalist societies, GDP has stronger informative power in those contexts where industry and services, and market exchange ...
openaire   +3 more sources