The E3 ubiquitin ligase mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation [PDF]
eLife, 2022 Vertebrate Delta/Notch signaling involves multiple ligands, receptors and transcription factors. Delta endocytosis – a critical event for Notch activation – is however essentially controlled by the E3 Ubiquitin ligase Mindbomb1 (Mib1).
Vishnu Muraleedharan Saraswathy +5 more
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Vangl2–environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension [PDF]
Disease Models & Mechanisms, 2022 Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD).
Oleksandr Nychyk +6 more
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The geometric basis of epithelial convergent extension [PDF]
eLifeShape changes of epithelia during animal development, such as convergent extension, are achieved through the concerted mechanical activity of individual cells.
Fridtjof Brauns +4 more
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Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension in Xenopus [PDF]
eLifeConvergent extension (CE) is a fundamental morphogenetic process where oriented cell behaviors lead to polarized extension of diverse tissues. In vertebrates, regulation of CE requires both non-canonical Wnt, its co-receptor Ror, and several ‘core ...
Hwa-seon Seo +11 more
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Segment-specific adhesion as a driver of convergent extension. [PDF]
PLoS Computational Biology, 2015 Convergent extension, the simultaneous extension and narrowing of tissues, is a crucial event in the formation of the main body axis during embryonic development.
Renske M A Vroomans +2 more
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Filopodial-Tension Model of Convergent-Extension of Tissues. [PDF]
PLoS Computational Biology, 2016 In convergent-extension (CE), a planar-polarized epithelial tissue elongates (extends) in-plane in one direction while shortening (converging) in the perpendicular in-plane direction, with the cells both elongating and intercalating along the converging ...
Julio M Belmonte +2 more
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The shapes of elongating gastruloids are consistent with convergent extension driven by a combination of active cell crawling and differential adhesion. [PDF]
PLoS Computational BiologyGastruloids have emerged as highly useful in vitro models of mammalian gastrulation. One of the most striking features of 3D gastruloids is their elongation, which mimics the extension of the embryonic anterior-posterior axis.
Martijn A de Jong +5 more
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αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish [PDF]
Biology Open, 2016 Cadherin complexes mediate cell-cell adhesion and are crucial for embryonic development. Besides their structural function, cadherin complexes also transduce tension across the junction-actomyosin axis into proportional biochemical responses.
Mitchell K. L. Han +5 more
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Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension [PDF]
Nature CommunicationsConvergent extension (CE) is a universal morphogenetic engine that promotes polarized tissue extension. In vertebrates, CE is regulated by non-canonical Wnt ligands signaling through “core” proteins of the planar cell polarity (PCP) pathway, including ...
Allyson Angermeier +6 more
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Convergent Extension Requires Adhesion-Dependent Biomechanical Integration of Cell Crawling and Junction Contraction [PDF]
Cell Reports, 2022 Shinuo Weng +2 more
exaly +2 more sources