Vangl as a Master Scaffold for Wnt/Planar Cell Polarity Signaling in Development and Disease [PDF]
Frontiers in Cell and Developmental Biology, 2022 The establishment of polarity within tissues and dynamic cellular morphogenetic events are features common to both developing and adult tissues, and breakdown of these programs is associated with diverse human diseases. Wnt/Planar cell polarity (Wnt/PCP)
Courtney A. Dreyer +2 more
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The Biological Significance and Implications of Planar Cell Polarity for Nephrology
Frontiers in Physiology, 2021 The orientation of cells in two-dimensional and three-dimensional space underpins how the kidney develops and responds to disease. The process by which cells orientate themselves within the plane of a tissue is termed planar cell polarity. In this Review,
Eugenia Papakrivopoulou +5 more
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Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity. [PDF]
Front Cell Dev Biol, 2022 Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon pathfinding and ciliogenesis. Like its Drosophila ortholog, Flamingo, mammalian
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Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions [PDF]
iScience, 2020 Summary: Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Jason Ear +6 more
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FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation [PDF]
Nature CommunicationsFGF receptors play pivotal roles in morphogenetic processes, including vertebrate neurulation. Planar cell polarity signaling coordinates cell orientation in the tissue plane and is essential for neural tube closure.
Ilya Chuykin, Sergei Y. Sokol
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Oscillatory shear stress-induced downregulation of TET1s injures vascular endothelial planar cell polarity by suppression of actin polymerization [PDF]
APL Bioengineering, 2023 Vascular endothelial polarity induced by blood flow plays crucial roles in the development of atherosclerosis. Loss of endothelial polarity leads to an increase in permeability and leukocyte recruitment, which are crucial hallmarks of atherosclerotic ...
Kai Qu +6 more
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Planar cell polarity: intracellular asymmetry and supracellular gradients of Frizzled [PDF]
Open Biology, 2023 Planar cell polarity (PCP), the coordinated orientation of structures such as cilia, mammalian hairs or insect bristles, depends on at least two molecular systems.
José Casal +2 more
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A role for Myo-II zipper and spaghetti squash in Gliotactin-dependent Drosophila melanogaster wing hair planar cell polarity. [PDF]
PLoS ONEPlanar cell polarity, polarization in the plane of an epithelium, is critical for tissue development. The Drosophila melanogaster wing epithelium is an important model system for planar cell polarity establishment and has greatly informed studies in ...
Chase Holland +13 more
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Directional alignment of different cell types organizes planar cell polarity [PDF]
iScienceSummary: Intercellular coupling between core PCP proteins is essential for unidirectional polarization of epithelial cells, known as planar cell polarity (PCP).
Masaki Arata +2 more
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Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation [PDF]
Journal of Developmental BiologyThe planar cell polarity (PCP) system is essential for positioning cells in 3D networks to establish the proper morphogenesis, structure, and function of organs during embryonic development.
Sandeep Kacker +7 more
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