PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting [PDF]
Frontiers in Cell and Developmental BiologyIntrodution: During development, planes of cells give rise to complex tissues and organs. The proper functioning of these tissues is critically dependent on proper inter- and intra-cellular spatial orientation, a feature known as planar cell polarity ...
Kendra L. Stansak +5 more
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How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? [PDF]
Open Biology, 2021 Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway.
Helen Strutt, David Strutt
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FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation [PDF]
Nature CommunicationsFGF receptors play pivotal roles in morphogenetic processes, including vertebrate neurulation. Planar cell polarity signaling coordinates cell orientation in the tissue plane and is essential for neural tube closure.
Ilya Chuykin, Sergei Y. Sokol
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Oscillatory shear stress-induced downregulation of TET1s injures vascular endothelial planar cell polarity by suppression of actin polymerization [PDF]
APL Bioengineering, 2023 Vascular endothelial polarity induced by blood flow plays crucial roles in the development of atherosclerosis. Loss of endothelial polarity leads to an increase in permeability and leukocyte recruitment, which are crucial hallmarks of atherosclerotic ...
Kai Qu +6 more
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Planar cell polarity: intracellular asymmetry and supracellular gradients of Frizzled [PDF]
Open Biology, 2023 Planar cell polarity (PCP), the coordinated orientation of structures such as cilia, mammalian hairs or insect bristles, depends on at least two molecular systems.
José Casal +2 more
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Directional alignment of different cell types organizes planar cell polarity [PDF]
iScienceSummary: Intercellular coupling between core PCP proteins is essential for unidirectional polarization of epithelial cells, known as planar cell polarity (PCP).
Masaki Arata +2 more
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Coupling Planar Cell Polarity Signaling to Morphogenesis
The Scientific World Journal, 2002 Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor ...
Jeffrey D. Axelrod, Helen McNeill
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A role for Myo-II zipper and spaghetti squash in Gliotactin-dependent Drosophila melanogaster wing hair planar cell polarity. [PDF]
PLoS ONEPlanar cell polarity, polarization in the plane of an epithelium, is critical for tissue development. The Drosophila melanogaster wing epithelium is an important model system for planar cell polarity establishment and has greatly informed studies in ...
Chase Holland +13 more
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Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation [PDF]
Journal of Developmental BiologyThe planar cell polarity (PCP) system is essential for positioning cells in 3D networks to establish the proper morphogenesis, structure, and function of organs during embryonic development.
Sandeep Kacker +7 more
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Cell autonomous polarization by the planar cell polarity signaling pathway [PDF]
Nature CommunicationsAs epithelial cells polarize in the tissue plane, the Planar Cell Polarity (PCP) signaling module segregates two distinct molecular subcomplexes to opposite sides of cells.
Alexis T. Weiner +5 more
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