Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling. [PDF]
DevelopmentJarysta A +8 more
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Ubiquitin Connects with Planar Cell Polarity [PDF]
Cell, 2009 Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.
Marek Mlodzik
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Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure. [PDF]
Cell Mol Life Sci, 2022 Shi DL.
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Disruption of Planar Cell Polarity Signaling Results in Congenital Heart Defects and Cardiomyopathy Attributable to Early Cardiomyocyte Disorganization [PDF]
Circulation Research, 2007 , Andrew Copp, Deborah Henderson
exaly +2 more sources
The Biological Significance and Implications of Planar Cell Polarity for Nephrology
Frontiers in Physiology, 2021 The orientation of cells in two-dimensional and three-dimensional space underpins how the kidney develops and responds to disease. The process by which cells orientate themselves within the plane of a tissue is termed planar cell polarity. In this Review,
Eugenia Papakrivopoulou +5 more
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Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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Frontiers in Cell and Developmental Biology, 2022 Planar cell polarity (PCP) signaling polarizes cells within the plane of an epithelium. In the airways, planar cell polarity signaling orients the directional beating of motile cilia required for effective mucociliary clearance.
Koshi Kunimoto +4 more
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Planar cell polarity and the kidney [PDF]
Nephrology Dialysis Transplantation, 2013 Planar cell polarity (PCP) is the uniform orientation and alignment of a group of cells orthogonal to the apical-basal axis within a tissue. Originally described in insects, it is now known that PCP is required for many processes in vertebrates, including directional cell movement, polarized cell division, ciliary orientation, neural tube closure ...
Papakrivopoulou, E +3 more
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Planar cell polarity in Drosophila [PDF]
Organogenesis, 2011 In all multicellular organisms, epithelial cells are not only polarized along the apical-basal axis, but also within the epithelial plane, giving cells a sense of direction. Planar cell polarity (PCP) signaling regulates establishment of polarity within the plane of an epithelium.
Saw Myat Thanda W, Maung, Andreas, Jenny
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Cell polarity and planar cell polarity (PCP) in spermatogenesis
Seminars in Cell & Developmental Biology, 2017 In adult mammalian testes, spermatids, most notably step 17-19 spermatids in stage IV-VIII tubules, are aligned with their heads pointing toward the basement membrane and their tails toward the tubule lumen. On the other hand, these polarized spermatids also align across the plane of seminiferous epithelium, mimicking planar cell polarity (PCP) found ...
Haiqi Chen +5 more
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