Results 11 to 20 of about 5,269,314 (284)

Cell autonomous polarization by the planar cell polarity signaling pathway [PDF]

Nature Communications, 2023
As epithelial cells polarize in the tissue plane, the Planar Cell Polarity (PCP) signaling module segregates two distinct molecular subcomplexes to opposite sides of cells.
Alexis T. Weiner, Silas Boye Nissen, Kaye Suyama, Bomsoo Cho, Gandhy Pierre-Louis, Jeffrey D. Axelrod   +5 more
doaj   +7 more sources

How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? [PDF]

Open Biology, 2021
Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway.
Helen Strutt, David Strutt
doaj   +3 more sources

The cell biology of planar cell polarity [PDF]

Journal of Cell Biology, 2014
Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between ...
Devenport, Danelle, Danelle Devenport
core   +3 more sources

FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation [PDF]

Nature Communications
FGF receptors play pivotal roles in morphogenetic processes, including vertebrate neurulation. Planar cell polarity signaling coordinates cell orientation in the tissue plane and is essential for neural tube closure.
Ilya Chuykin, Sergei Y. Sokol
doaj   +2 more sources

Planar cell polarity: intracellular asymmetry and supracellular gradients of Frizzled [PDF]

Open Biology, 2023
Planar cell polarity (PCP), the coordinated orientation of structures such as cilia, mammalian hairs or insect bristles, depends on at least two molecular systems.
José Casal, Freya Storer, Peter A. Lawrence   +2 more
doaj   +2 more sources

Planar cell polarity in organ formation [PDF]

Current Opinion in Cell Biology, 2018
The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent ...
Henderson DJ, Long, David A, Long DA, Dean, CH, Dean CH, Henderson, Deborah J, Dean, Charlotte H, Henderson, DJ, Long, DA   +8 more
core   +6 more sources

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

Nature Communications, 2017
It is unclear if there is an interaction between apical-basal (AB) polarity and planar cell polarity (PCP) pathways during morphogenesis. Here, the authors define a role for the melanoma cell adhesion molecule (MCAM), known to regulate PCP, in AB ...
Qian Gao, Junfeng Zhang, Xiumei Wang, Ying Liu, Rongqiao He, Xingfeng Liu, Fei Wang, Jing Feng, Dongling Yang, Zhaoqing Wang, Anming Meng, Xiyun Yan   +11 more
doaj   +2 more sources

Cell polarity and planar cell polarity (PCP) in spermatogenesis

Seminars in Cell & Developmental Biology, 2018
In adult mammalian testes, spermatids, most notably step 17–19 spermatids in stage IV–VIII tubules, are aligned with their heads pointing toward the basement membrane and their tails toward the tubule lumen.
Dolores D. Mruk, C. Yan Cheng, Will M. Lee, Chen, Haiqi, Wong, CKC, Mruk, Dolores D., Lee, Will M., Haiqi Chen, Lee, WWM, Wong, Chris K.C., Lui, WY, Chris K.C. Wong, Cheng, CY, Mruk, DD, Cheng, C. Yan, Wing-yee Lui, Lui, Wing-Yee, Chen, H   +17 more
core   +6 more sources

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity [PDF]

Developmental Cell, 2011
Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components ...
Isabelle Roszko, Roszko, Isabelle, Lilianna Solnica-Krezel, Ryan S. Gray, Gray, Ryan S., Solnica-Krezel, Lilianna   +5 more
core   +4 more sources

Directional alignment of different cell types organizes planar cell polarity [PDF]

iScience
Summary: Intercellular coupling between core PCP proteins is essential for unidirectional polarization of epithelial cells, known as planar cell polarity (PCP).
Masaki Arata, Hiroshi Koyama, Toshihiko Fujimori   +2 more
doaj   +2 more sources