Results 1 to 10 of about 433,759 (305)
Cell autonomous polarization by the planar cell polarity signaling pathway. [PDF]
Nat Commun, 2023 Abstract As epithelial cells polarize in the tissue plane, the Planar Cell Polarity (PCP) signaling module segregates two distinct molecular subcomplexes to opposite sides of cells. Homodimers of the atypical cadherin Flamingo form bridges linking opposite complexes in neighboring cells, coordinating their direction of polarization ...
Weiner AT +5 more
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Establishing cell polarity in plants: the role of cytoskeletal structures and regulatory pathways [PDF]
Frontiers in Cell and Developmental BiologyCell polarity is a fundamental mechanism of plant cells that drives cellular specialization and the formation of diverse cell types. It regulates critical developmental events, including polarized tip growth (such as pollen tubes and root hairs ...
Chao Ma +4 more
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Cell polarity: cell type-specific regulators, common pathways, and polarized vesicle transport. [PDF]
LeukemiaCell polarity, the asymmetric organization of cellular components, is evolutionarily conserved from unicellular and multicellular organisms and is crucial for many biological processes. Polarity is required to maintain cell and tissue integrity by regulating cell division, migration, orientation, cell-cell interactions, and morphogenesis.
Bera S, Loeffler D.
europepmc +3 more sources
npj Regenerative Medicine, 2022 TJP2/ZO-2-inactivating mutations in humans cause progressive cholestatic liver disease. Liver-specific deletion of Tjp2 in the mouse (Tjp2 cKO mice) leads to mild progressive cholestasis without an overt degradation of the bile-blood barrier (BBB). These
Jianliang Xu +5 more
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Cell Polarity from Cell Division [PDF]
Developmental Cell, 2007 Apical-basal polarity of epithelial cells is critical for their symmetric versus asymmetric division and commonly thought to be established in interphase. In a novel type of cell division termed "mirror-symmetric", apical cell constituents accumulate during M-phase at the cleavage furrow, resulting in epithelial daughter cells with opposite apical ...
Knust, E., Huttner, W.
openaire +3 more sources
BMC Molecular and Cell Biology, 2020 Background Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its expression is downregulated in both
Christian Hartmann +11 more
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Cell Adhesion at the Tight Junctions: New Aspects and New Functions
Cells, 2023 Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a surprisingly high molecular complexity and unexpected dynamic ...
Nicolina Wibbe, Klaus Ebnet
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Quantification of Nematic Cell Polarity in Three-dimensional Tissues [PDF]
, 2020 How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is different from vectorial cell polarity ...
Brusch, Lutz +11 more
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Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
Cells, 2021 Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins.
Emma J. van Bodegraven +1 more
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Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment
iScience, 2022 Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer +8 more
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