Results 1 to 10 of about 5,185,183 (259)

Neural Tube Defects: From a Proteomic Standpoint

Metabolites, 2015
Neural tube defects (NTDs) are congenital birth defects classified according to their resulting morphological characteristics in newborn patients. Current diagnosis of NTDs relies largely on the structural evaluation of fetuses using ultrasound imaging ...
Tania M. Puvirajesinghe, Jean-Paul Borg
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Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells

Biomolecules, 2019
Drosophila Schneider 2 (S2) cells are a simple and powerful system commonly used in cell biology because they are well suited for high resolution microscopy and RNAi-mediated depletion.
Mariana Osswald, A. Filipa Santos, Eurico Morais-de-Sá   +2 more
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Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins

Frontiers in Microbiology, 2022
The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains, which is identical to the PBM of SARS-CoV.
Yanlei Zhu, Flavio Alvarez, Nicolas Wolff, Ariel Mechaly, Sébastien Brûlé, Benoit Neitthoffer, Sandrine Etienne-Manneville, Ahmed Haouz, Batiste Boëda, Célia Caillet-Saguy   +9 more
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Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection

Cells, 2018
Junctional adhesion molecules (JAMs) are cell surface adhesion receptors of the immunoglobulin superfamily. JAMs are involved in a variety of biological processes both in the adult organism but also during development.
Daniel Kummer, Klaus Ebnet
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aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

Nature Communications, 2018
The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both ...
Meghan Riddell, Akiko Nakayama, Takao Hikita, Fatemeh Mirzapourshafiyi, Takuji Kawamura, Ayesha Pasha, Mengnan Li, Mikio Masuzawa, Mario Looso, Tim Steinbacher, Klaus Ebnet, Michael Potente, Tomonori Hirose, Shigeo Ohno, Ingrid Fleming, Stefan Gattenlöhner, Phyu P. Aung, Thuy Phung, Osamu Yamasaki, Teruki Yanagi, Hiroshi Umemura, Masanori Nakayama   +21 more
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Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

Nature Communications, 2016
Defects in non-canonical Wnt/planar cell polarity signalling have recently been linked to breast cancer aggressiveness. Puvirajesinghe et al. identify VANGL2, p62/SQSTM1 and JNK as important players in this pathway which may be amenable to therapeutic ...
Tania M. Puvirajesinghe, François Bertucci, Ashish Jain, Pierluigi Scerbo, Edwige Belotti, Stéphane Audebert, Michael Sebbagh, Marc Lopez, Andreas Brech, Pascal Finetti, Emmanuelle Charafe-Jauffret, Max Chaffanet, Rémy Castellano, Audrey Restouin, Sylvie Marchetto, Yves Collette, Anthony Gonçalvès, Ian Macara, Daniel Birnbaum, Laurent Kodjabachian, Terje Johansen, Jean-Paul Borg   +21 more
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TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics

eLife, 2016
Segmentation and tracking of cells in long-term time-lapse experiments has emerged as a powerful method to understand how tissue shape changes emerge from the complex choreography of constituent cells.
Raphaël Etournay, Matthias Merkel, Marko Popović, Holger Brandl, Natalie A Dye, Benoît Aigouy, Guillaume Salbreux, Suzanne Eaton, Frank Jülicher   +8 more
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Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

Advanced Science, 2021
Triple‐negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of the human disease.
Fabienne Lamballe, Fahmida Ahmad, Yaron Vinik, Olivier Castellanet, Fabrice Daian, Anna‐Katharina Müller, Ulrike A. Köhler, Anne‐Laure Bailly, Emmanuelle Josselin, Rémy Castellano, Christelle Cayrou, Emmanuelle Charafe‐Jauffret, Gordon B. Mills, Vincent Géli, Jean‐Paul Borg, Sima Lev, Flavio Maina   +16 more
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A direct interaction of JAM-C with the tight junction scaffold protein ZO-2

Scientific Reports
Tight junctions are sites of cell-cell contacts at the apical region of epithelial junctions that are involved in barrier formation, cellular signaling, and cell-cell adhesion.
Annika Schulte, Mariel F. Schwietzer, Frauke Brinkmann, Valentin Teuber, Sandra Citi, Mikio Furuse, Michel Aurrand-Lions, Klaus Ebnet   +7 more
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Mechanobiology of the nucleus during the G2-M transition

Nucleus
Cellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events.
Joana T. Lima, Jorge G. Ferreira
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