Results 11 to 20 of about 433,759 (305)
PTEN inhibits AMPK to control collective migration
Nature Communications, 2022 Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.
Florent Peglion +9 more
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Cell polarity inside-out [PDF]
Current Opinion in Cell Biology, 2020 Cell Polarity is defined as the structural, morphological, and functional asymmetry along an axis. This fundamental process can be separated into initiation or establishment, commonly referred to as symmetry breaking, and maintenance. For both steps, tight spatial and temporal control of signaling and cellular organization is critical and can be ...
Etienne-Manneville, Sandrine +1 more
openaire +3 more sources
Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells
Frontiers in Cell and Developmental Biology, 2022 Membrane polarity, defined as the asymmetric distribution of lipids and proteins in the plasma membrane, is a critical prerequisite for the development of multicellular tissues, such as epithelia and endothelia.
Klaus Ebnet +5 more
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Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1
Communications Biology, 2023 Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed apical-basal polarity and tumor formation.
Eva-Maria Thüring +9 more
doaj +1 more source
Spectrin binding motifs regulate Scribble cortical dynamics and polarity function
eLife, 2015 The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood.
Batiste Boëda +1 more
doaj +1 more source
Polarized cells, polar actions
Journal of Bacteriology, 1993 The recognition of polar bacterial organization is just emerging. The examples of polar localization given here are from a variety of bacterial species and concern a disparate array of cellular functions. A number of well-characterized instances of polar localization of bacterial proteins, including the chemoreceptor complex in both C. crescentus and E.
J R, Maddock, M R, Alley, L, Shapiro
openaire +3 more sources
The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]
, 2013 The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
A Merla +58 more
core +3 more sources
Cell polarity: Fixing cell polarity with Pins [PDF]
Current Biology, 2000 A protein complex is assembled in a step-wise manner at the apical pole of Drosophila neuroblasts. This complex organizes the apical-basal polarity of asymmetrically dividing neuroblasts, and may act via G-protein signalling.
openaire +2 more sources
Neural Tube Defects: From a Proteomic Standpoint
Metabolites, 2015 Neural tube defects (NTDs) are congenital birth defects classified according to their resulting morphological characteristics in newborn patients. Current diagnosis of NTDs relies largely on the structural evaluation of fetuses using ultrasound imaging ...
Tania M. Puvirajesinghe, Jean-Paul Borg
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A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. [PDF]
, 2012 The elongation of tissues and organs during embryonic development results from the coordinate polarization of cell behaviors with respect to the elongation axis.
Bilder, David +4 more
core +2 more sources