Results 11 to 20 of about 202,026 (264)
Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment
iScience, 2022 Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer +8 more
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Mechanisms of cell polarization [PDF]
Current Opinion in Systems Biology, 2017 Cell polarization is a key step in the migration, development, and organization of eukaryotic cells, both at the single cell and multicellular level. Research on the mechanisms that give rise to polarization of a given cell, and organization of polarity within a tissue has led to new understanding across cellular and developmental biology.
Wouter-Jan, Rappel +1 more
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Origins of Cell Polarity [PDF]
Cell, 1996 The authors thank Kathryn Ayscough, Ken Beck, Fred Chang, Yih-Tai Chen, Kent Grindstaff, and Jeremy Thorner for comments on the manuscript as well as colleagues who kindly provided preprints.
Drubin, David G, Nelson, W.James
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Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1
Communications Biology, 2023 Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed apical-basal polarity and tumor formation.
Eva-Maria Thüring +9 more
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Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells
Frontiers in Cell and Developmental Biology, 2022 Membrane polarity, defined as the asymmetric distribution of lipids and proteins in the plasma membrane, is a critical prerequisite for the development of multicellular tissues, such as epithelia and endothelia.
Klaus Ebnet +5 more
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Polarized cells, polar actions
Journal of Bacteriology, 1993 The recognition of polar bacterial organization is just emerging. The examples of polar localization given here are from a variety of bacterial species and concern a disparate array of cellular functions. A number of well-characterized instances of polar localization of bacterial proteins, including the chemoreceptor complex in both C. crescentus and E.
J R, Maddock, M R, Alley, L, Shapiro
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Cell Polarity from Cell Division [PDF]
Developmental Cell, 2007 Apical-basal polarity of epithelial cells is critical for their symmetric versus asymmetric division and commonly thought to be established in interphase. In a novel type of cell division termed "mirror-symmetric", apical cell constituents accumulate during M-phase at the cleavage furrow, resulting in epithelial daughter cells with opposite apical ...
Knust, E., Huttner, W.
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Spectrin binding motifs regulate Scribble cortical dynamics and polarity function
eLife, 2015 The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood.
Batiste Boëda +1 more
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Cell polarity: Fixing cell polarity with Pins [PDF]
Current Biology, 2000 A protein complex is assembled in a step-wise manner at the apical pole of Drosophila neuroblasts. This complex organizes the apical-basal polarity of asymmetrically dividing neuroblasts, and may act via G-protein signalling.
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, 2023 Immune cells are responsible for pathogen detection and elimination, as well as for signaling to other cells the presence of potential danger. In order to mount an efficient immune response, they need to move and search for a pathogen, interact with other cells, and diversify the population by asymmetric cell division.
Pineau, Judith +3 more
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