Results 41 to 50 of about 202,026 (264)

Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome

Nature Communications, 2020
While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations.
Mengnan Li, Shin-ya Nishio, Chie Naruse, Meghan Riddell, Sabrina Sapski, Tatsuya Katsuno, Takao Hikita, Fatemeh Mizapourshafiyi, Fiona M. Smith, Leanne T. Cooper, Min Goo Lee, Masahide Asano, Thomas Boettger, Marcus Krueger, Astrid Wietelmann, Johannes Graumann, Bryan W. Day, Andrew W. Boyd, Stefan Offermanns, Shin-ichiro Kitajiri, Shin-ichi Usami, Masanori Nakayama   +21 more
doaj   +1 more source

A Bistable Model of Cell Polarity

PLoS ONE, 2012
Ultrasensitivity, as described by Goldbeter and Koshland, has been considered for a long time as a way to realize bistable switches in biological systems. It is not as well recognized that when ultrasensitivity and reinforcing feedback loops are present in a spatially distributed system such as the cell plasmamembrane, they may induce bistability and ...
Semplice M., Veglio A., Naldi G., Serini G., GAMBA, ANDREA ANTONIO   +4 more
openaire   +4 more sources

Cyclical Regulation of the Exocyst and Cell Polarity Determinants for Polarized Cell Growth [PDF]

Molecular Biology of the Cell, 2005
Polarized exocytosis is important for morphogenesis and cell growth. The exocyst is a multiprotein complex implicated in tethering secretory vesicles at specific sites of the plasma membrane for exocytosis. In the budding yeast, the exocyst is localized to sites of bud emergence or the tips of small daughter cells, where it mediates secretion and cell ...
Allison, Zajac, Xiaoli, Sun, Jian, Zhang, Wei, Guo   +3 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Development of electromagnetic tweezers for single-molecule energetics of kinesin

Biophysics and Physicobiology
Optical tweezers have enabled single-molecule measurements of kinesin mechanics and energetics but face challenges for in vivo applications due to photothermal effects and refractive-index-dependent force calibration.
Haruyuki Fukuzawa, Yuga Ihara, Masato Sawa, Hidekazu Shirai, Sawako Enoki, Keigo Ikezaki, Taketoshi Kambara, Yasushi Okada   +7 more
doaj   +1 more source

Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? [PDF]

Open Biology, 2013
Spatio-temporal coordination of events during cell division is crucial for animal development. In recent years, emerging data have strengthened the notion that tight coupling of cell cycle progression and cell polarity in dividing cells is crucial for ...
Anna Noatynska, Nicolas Tavernier, Monica Gotta, Lionel Pintard   +3 more
doaj   +1 more source

Combined effect of cell geometry and polarity domains determines the orientation of unequal division

eLife, 2021
Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis.
Benoit G Godard, Remi Dumollard, Carl-Philipp Heisenberg, Alex McDougall   +3 more
doaj   +1 more source

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity [PDF]

Developmental Cell, 2011
Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic ...
Gray, Ryan S., Roszko, Isabelle, Solnica-Krezel, Lilianna   +2 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Autonomous epithelial folding induced by an intracellular mechano-polarity feedback loop.

PLoS Computational Biology, 2021
Epithelial tissues form folded structures during embryonic development and organogenesis. Whereas substantial efforts have been devoted to identifying mechanical and biochemical mechanisms that induce folding, whether and how their interplay ...
Fu-Lai Wen, Chun Wai Kwan, Yu-Chiun Wang, Tatsuo Shibata   +3 more
doaj   +1 more source