Results 51 to 60 of about 220,716 (312)

A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity. [PDF]

PLoS Biology, 2013
The spatiotemporal control of cell polarity is crucial for the development of multicellular organisms and for reliable polarity switches during cell cycle progression in unicellular systems.
Franz Meitinger, Heidi Richter, Sabrina Heisel, Birgit Hub, Wolfgang Seufert, Gislene Pereira   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Unified quantitative characterization of epithelial tissue development

eLife, 2015
Understanding the mechanisms regulating development requires a quantitative characterization of cell divisions, rearrangements, cell size and shape changes, and apoptoses.
Boris Guirao, Stéphane U Rigaud, Floris Bosveld, Anaïs Bailles, Jesús López-Gay, Shuji Ishihara, Kaoru Sugimura, François Graner, Yohanns Bellaïche   +8 more
doaj   +1 more source

Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome

Nature Communications, 2020
While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations.
Mengnan Li, Shin-ya Nishio, Chie Naruse, Meghan Riddell, Sabrina Sapski, Tatsuya Katsuno, Takao Hikita, Fatemeh Mizapourshafiyi, Fiona M. Smith, Leanne T. Cooper, Min Goo Lee, Masahide Asano, Thomas Boettger, Marcus Krueger, Astrid Wietelmann, Johannes Graumann, Bryan W. Day, Andrew W. Boyd, Stefan Offermanns, Shin-ichiro Kitajiri, Shin-ichi Usami, Masanori Nakayama   +21 more
doaj   +1 more source

Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? [PDF]

Open Biology, 2013
Spatio-temporal coordination of events during cell division is crucial for animal development. In recent years, emerging data have strengthened the notion that tight coupling of cell cycle progression and cell polarity in dividing cells is crucial for ...
Anna Noatynska, Nicolas Tavernier, Monica Gotta, Lionel Pintard   +3 more
doaj   +1 more source

A Bistable Model of Cell Polarity

PLoS ONE, 2012
Ultrasensitivity, as described by Goldbeter and Koshland, has been considered for a long time as a way to realize bistable switches in biological systems. It is not as well recognized that when ultrasensitivity and reinforcing feedback loops are present in a spatially distributed system such as the cell plasmamembrane, they may induce bistability and ...
Semplice M., Veglio A., Naldi G., Serini G., GAMBA, ANDREA ANTONIO   +4 more
openaire   +4 more sources

Cyclical Regulation of the Exocyst and Cell Polarity Determinants for Polarized Cell Growth [PDF]

Molecular Biology of the Cell, 2005
Polarized exocytosis is important for morphogenesis and cell growth. The exocyst is a multiprotein complex implicated in tethering secretory vesicles at specific sites of the plasma membrane for exocytosis. In the budding yeast, the exocyst is localized to sites of bud emergence or the tips of small daughter cells, where it mediates secretion and cell ...
Allison, Zajac, Xiaoli, Sun, Jian, Zhang, Wei, Guo   +3 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Development of electromagnetic tweezers for single-molecule energetics of kinesin

Biophysics and Physicobiology
Optical tweezers have enabled single-molecule measurements of kinesin mechanics and energetics but face challenges for in vivo applications due to photothermal effects and refractive-index-dependent force calibration.
Haruyuki Fukuzawa, Yuga Ihara, Masato Sawa, Hidekazu Shirai, Sawako Enoki, Keigo Ikezaki, Taketoshi Kambara, Yasushi Okada   +7 more
doaj   +1 more source

Combined effect of cell geometry and polarity domains determines the orientation of unequal division

eLife, 2021
Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis.
Benoit G Godard, Remi Dumollard, Carl-Philipp Heisenberg, Alex McDougall   +3 more
doaj   +1 more source