Results 71 to 80 of about 220,716 (312)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Cell polarity inside-out

, 2020
International audienceCell Polarity is defined as the structural, morphological, and functional asymmetry along an axis. This fundamental process can be separated into initiation or establishment, commonly referred to as symmetry breaking, and ...
Etienne-Manneville, Sandrine, Arkowitz, Robert   +1 more
core   +1 more source

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine [PDF]

, 2010
Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis.
Segref, Alexandra, Johnstone, Iain L., Cabello, Juan, Ralf Schnabel, Iain L. Johnstone, Alexandra Segref, Caroline Clucas, Juan Cabello, Schnabel, Ralf, Clucas, Caroline   +9 more
core   +1 more source

Cell polarity and extrusion: How to polarize extrusion and extrude misspolarized cells?

, 2023
The barrier function of epithelia is one of the cornerstones of the body plan organization of metazoans. It relies on the polarity of epithelial cells which organizes along the apico-basal axis the mechanical properties, signaling as well as transport.
Staneva, Ralitza, Levayer, Romain
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Dissection of Arabidopsis ADP-Ribosylation Factor 1 function in epidermal cell polarity [PDF]

, 2005
Vesicle trafficking is essential for the generation of asymmetries, which are central to multicellular development. Core components of the vesicle transport machinery, such as ADP-ribosylation factor (ARF) GTPases, have been studied primarily at the ...
Scheres, B.J.G., Pattern and polarity in Arabidopsis root development, Xu, J., Dep Biologie, Universiteit Utrecht   +4 more
core  

Homer3 regulates the establishment of neutrophil polarity [PDF]

, 2015
Contains fulltext : 152995.pdf (Publisher’s version ) (Open Access)Most chemoattractants rely on activation of the heterotrimeric G-protein Galphai to regulate directional cell migration, but few links from Galphai to chemotactic ...
Pipathsouk, Anne, Alkema, W., Weiner, Orion, Liu, S, Keizer-Gunnink, A, Kortholt, Arjan, Fusetti, F, Keizer-Gunnink, A., Liu, Shanshan, Weiner, Orion D, Kortholt, Arjan; id_orcid, Altschuler, S., Weiner, O.D., Wu, J, Wu, Julie, Altschuler, Steven, Pipathsouk, A., Kortholt, A., Alkema, W, Fusetti, F., Kortholt, A, Wu, J., Liu, S., Alkema, W.B.L., Wu, L., Wu, Lani, Pipathsouk, A, Weiner, OD   +27 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling

Stem Cell Reports, 2018
Summary: Tumor initiation, progression, and therapeutic resistance have been proposed to originate from a subset of tumor cells, cancer stem cells (CSCs).
Leonor Lopez Almeida, Michael Sebbagh, François Bertucci, Pascal Finetti, Julien Wicinski, Sylvie Marchetto, Rémy Castellano, Emmanuelle Josselin, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Jean-Paul Borg, Marie-Josée Santoni   +11 more
doaj   +1 more source

Spherical Caps in Cell Polarization [PDF]

Biophysical Journal, 2018
Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane.
Diegmiller, Rocky, Montanelli, Hadrien, Muratov, Cyrill B, Shvartsman, Stanislav Y   +3 more
openaire   +3 more sources