Results 91 to 100 of about 220,716 (312)

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

G3: Genes, Genomes, Genetics, 2017
In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth.
Linda M. Parsons, Nicola A. Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M. Quinn, Helena E. Richardson   +5 more
doaj   +1 more source

Cell polarity in morphogenesis and metastasis [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2013
Most human cancers arise either from epithelial cells or their progenitors. Epithelial cells possess a distinctive apical–basal polarity and loss of polarity is frequently assumed to be a common feature of cancer progression. In particular, cancer cell dissemination to ectopic sites, and metastatic growth at those sites, is often considered to require ...
Ian G, Macara, Luke, McCaffrey
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cell Division Compromises Epithelial Cell Polarity and Drives Tumor Progression

, 2021
Epithelia are the predominant tissue type of the animal body and form major components of most organs. As with all tissues, the formation of epithelia during development and their stem cell-based renewal requires cell division. This presents a problem as
Jeyanathan, Gayaanan
core  

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

eLife, 2017
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g.
Jennifer J Banerjee, Birgit L Aerne, Maxine V Holder, Simon Hauri, Matthias Gstaiger, Nicolas Tapon   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. [PDF]

, 2015
Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes.
Daniel J. Jagger, Zakia A. Abdelhamed, Johnson, CA, Carmel Toomes, Jagger, DJ, Johnson, Colin A., Toomes, C, Wheway, G, Christopher F. Inglehearn, Colin A. Johnson, Jagger, Daniel J., Toomes, Carmel, Abdelhamed, ZA, Abdelhamed, Zakia A., Subaashini Natarajan, Inglehearn, CF, Natarajan, Subaashini, Gabrielle Wheway, Inglehearn, Christopher F., Natarajan, S, Inglehearn, Chris F., Wheway, Gabrielle   +21 more
core   +1 more source

RhoGDI1 regulates cell-cell junctions in polarized epithelial cells

Frontiers in Cell and Developmental Biology
Cell-cell contact formation of polarized epithelial cells is a multi-step process that involves the co-ordinated activities of Rho family small GTPases. Consistent with the central role of Rho GTPases, a number of Rho guanine nucleotide exchange factors (
Nicolina Wibbe, Tim Steinbacher, Frederik Tellkamp, Frederik Tellkamp, Niklas Beckmann, Frauke Brinkmann, Manuel Stecher, Volker Gerke, Volker Gerke, Carien M. Niessen, Carien M. Niessen, Carien M. Niessen, Klaus Ebnet, Klaus Ebnet   +13 more
doaj   +1 more source