Results 81 to 90 of about 220,716 (312)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

A PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte [PDF]

, 2011
Cytoskeletal organization is central to establishing cell polarity in various cellular contexts, including during messenger ribonucleic acid sorting in Drosophila melanogaster oocytes by microtubule (MT)-dependent molecular motors.
Lu, Weiping, Hamilton, RS, Hamilton, R, C. Fiona Cullen, Weiping Lu, Parton, Richard M., Cullen, CF, Parton, R, Ball, G, Ohkura, Hiroyuki, Yang, L, Lei Yang, Ilan Davis, Davis, Ilan, Parton, RM, Russell S. Hamilton, Hamilton, Russell S., Ohkura, H, Cullen, C. Fiona, Richard M. Parton, Graeme Ball, Yang, Lei, Hiroyuki Ohkura, Davis, I, Cullen, Fiona, Ball, Graeme, Lu, W   +26 more
core   +1 more source

Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase

, 2021
Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
core   +1 more source

Wallenda-Nmo Axis Regulates Growth via Hippo Signaling

Frontiers in Cell and Developmental Biology, 2021
Both Hippo signaling pathways and cell polarity regulation are critical for cell proliferation and the maintenance of tissue homeostasis, despite the well-established connections between cell polarity disruption and Hippo inactivation, the molecular ...
Xianping Wang, Xianping Wang, Xianping Wang, Hui Liang, Hui Liang, Hui Liang, Wenyan Xu, Wenyan Xu, Wenyan Xu, Xianjue Ma, Xianjue Ma, Xianjue Ma   +11 more
doaj   +1 more source

Cell polarity proteins and spermatogenesis [PDF]

Seminars in Cell & Developmental Biology, 2016
When the cross-section of a seminiferous tubule from an adult rat testes is examined microscopically, Sertoli cells and germ cells in the seminiferous epithelium are notably polarized cells. For instance, Sertoli cell nuclei are found near the basement membrane.
Cheng, CY, Xiao, X, Gao, Y, Mruk, DD, Lee, WWM, Lui, WY   +5 more
openaire   +4 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

, 2017
The apical–basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear.
Meng, Anming, Ying Liu, Wang, Xiumei, Xiumei Wang, Xingfeng Liu, Yan, Xiyun, He, Rongqiao, Qian Gao, Wang, Zhaoqing, Rongqiao He, Gao, Qian, Liu, Ying, Yang, Dongling, Wang, Fei, Zhang, Junfeng, Liu, Xingfeng, Feng, Jing, Jing Feng, Fei Wang, Anming Meng, Dongling Yang, Junfeng Zhang, Zhaoqing Wang, Xiyun Yan   +23 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14

Cell Reports
Summary: Glioblastoma (GBM), the most aggressive primary brain tumor, is marked by high invasiveness that enables resistance to current therapies. Single-cell RNA sequencing analysis reveals that elevated expression of glial intermediate filament (IF ...
Emma J. van Bodegraven, Elvira Infante, Florent Peglion, David Pereira, Yekta Kesenci, Vanessa Roca, Isabelle Perfettini, Emmanuel Terriac, Juliana Geay, Laura Soto, Jacqueline Sluijs, Reinier Rietveld, Shailaja Seetharaman, Batiste Boëda, Jean-Christophe Olivo-Marin, Atef Asnacios, Aleix Boquet-Pujadas, Jean-Baptiste Manneville, Sandrine Etienne-Manneville   +18 more
doaj   +1 more source