Results 101 to 110 of about 433,759 (305)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Applying mechanical forces on Drosophila tissues in vivo using the StretchCo, a 3D-printable device

STAR Protocols
Summary: Applying mechanical forces to tissues helps to understand morphogenesis and homeostasis. Additionally, recording the dynamics of living tissues under mechanical constraints is needed to explore tissue biomechanics. Here, we present a protocol to
Mélanie Gracia, Bénédicte M. Lefèvre, Raquel Güell Alonso, Victoire Cachoux, Maria Balakireva, Boris Guirao, Damien Cuvelier, Allison J. Bardin, Yohanns Bellaïche   +8 more
doaj   +1 more source

Fast recharge circuit for q-switched lasers [PDF]

, 1973
Cavity-dumped lasers employ electrooptic-effect cell to alternately block and release laser pulse. Cell requires high-speed switching circuit that can apply and remove high voltage.
Hansen, R. L.
core   +1 more source

Complex polarity: building multicellular tissues through apical membrane traffic [PDF]

, 2016
The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization.
Adams, Allaire, Altschuler, Ang, Aranda, Assemat, Bai, Baker, Balda, Balklava, Bedzhov, Benton, Betschinger, Blankenship, Boehlke, Bryant, Bryant, Bryant, Bulgakova, Butty, Campbell, Cancino, Chen, Chiba, Colley, Denef, Devenport, Dhekne, Eaton, Elias, Feldman, Ferrari, Fletcher, Galvez-Santisteban, Gamblin, Gangar, Gao, Gao, Gassama-Diagne, Georgiou, Gillard, Goldstein, Grawe, Graybill, Hammer, Hao, Hariharan, Harris, Harris, Harris, Hehnly, Hehnly, Hung, Hurd, Hurov, Hutterer, Hyenne, Izumi, Izumi, Joberty, Johnson, Kemphues, Klebes, Klinkert, Klose, Krahn, Kroschewski, Kumar, Kumichel, Kusakabe, Langevin, Leibfried, Lerner, Li, Li, Li, Lin, Lin, Ling, Liu, Lock, Lu, Macara, Martin-Belmonte, McGill, Melendez, Menut, Michaux, Moberg, Morais-de-Sa, Morrison, Mrozowska, Muller, Musch, Nakayama, Nakayama, Nakayama, Neisch, Ozdamar, Parsons, Pellikka, Pinal, Plant, Pocha, Pocha, Richards, Robinson, Rodriguez-Boulan, Rodriguez-Fraticelli, Rodriguez-Fraticelli, Roeth, Roland, Rossi, Sahlender, Sakamori, Sato, Satoh, Schluter, Schottenfeld-Roames, Shafaq-Zadah, Sherrard, Shewan, Shivas, Sobajima, Sollier, Stepensky, Suzuki, Takahama, Taniguchi, Tepass, Tepass, Tepass, Thuenauer, Toro, Vaccari, Vaccari, Varelas, Vermeer, Vogel, Vogel, Vreede, Wang, Wang, Wang, Wedlich-Soldner, Wei, Wiegerinck, Willenborg, Winter, Xiong, Xiong, Yamanaka, Yamanaka, Zhang, Zhang, Zhou, Zihni, Zou   +157 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion

Cellular and Molecular Life Sciences
Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive ...
Klaus Ebnet, Michel Aurrand-Lions
doaj   +1 more source

Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype [PDF]

, 2015
Cell polarity impacts on the maintenance of cell shape, cell-cell junction integrity, and protrusion formation and dynamics. Further, polarity additionally regulates cell movement, proliferation and differentiation.
Georgiou, Marios, Layfield, Robert, Shohayeb, Belal   +2 more
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells [PDF]

, 2016
The asymmetric localization of proteins in the plasma membrane domains of eukaryotic cells is a fundamental manifestation of cell polarity that is central to multicellular organization and developmental patterning.
Friml, Jiri, Langowski, Lukasz, Li, Hongjiang, Naramoto, Satoshi, Tanaka, Hirokazu, Vanneste, Steffen, Wabnik, Krzysztof   +6 more
core   +4 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source