Results 101 to 110 of about 220,716 (312)

High expression of Rac1 is correlated with partial reversed cell polarity and poor prognosis in invasive ductal carcinoma of the breast

Tumor Biology, 2017
The change of cell polarity is usually associated with invasion and metastasis. Partial reverse cell polarity in IDC-NOS may play a role in lymphatic tumor spread. Rac1 is a kind of polarity related protein.
Bingbing Liu, Jianhua Xiong, Guiqiu Liu, Jing Wu, Likun Wen, Qin Zhang, Chuanshan Zhang   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Role of rac1 protein in the acquisition and mainteinance of epithelial cell polarity

, 2009
: The acquisition of cell polarity, which includes the establishment of the tight junction barrier, the polarized assembly of the cytoskeleton and the appropriate organization of membrane traffic, requires external cues, that in epithelial cells are ...
Santoriello, Margherita
core  

Tight junctions and cell polarity

, 2018
The tight junction is an intracellular junctional structure that mediates adhesion between epithelial cells and is required for epithelial cell function.
Fogg, VC, Margolis, B, Shin, K
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Apical/basal polarity : why plant cells do not stand on their heads

, 2005
The anatomical terminology that is used to describe the orientation and polarity in the plant body (for distinction indicated here in italics) is based on the consensus agreement that the transition zone between the aerial and the soil-borne part (the ...
Bennett, M., Grebe, Markus, Friml, J., Hejátko, Jan, Grebe, M., Torres-Ruiz, R., Grebe, Markus, Berleth, Thomas, Jürgens, Gerd, Luschnig, C., Heisler, Marcus, Weijers, D., Scheres, B.J.G., Offringa, Remko, Zažímalová, Eva, Berleth, T., Lukowitz, Wolfgang, Torres-Ruiz, Ramón, Friml, Jiří, Bennett, Malcolm, Lukowitz, Wolfgang, Benfey, P., Geldner, N., Scheres, Ben, Pattern and polarity in Arabidopsis root development, Torres-Ruiz, Ramón, Lukowitz, W., Laux, T., Dep Biologie, Bennett, Malcolm, Swarup, Raanjan, Luschnig, Christian, Geldner, Niko, Geldner, Niko, Laux, Thomas, Jürgens, Gerd, Scheres, B., Lindsey, K., Lindsey, Keith, Luschnig, Christian, Zazímalová, Eva, Hejátko, Jan, Swarup, Ranjan, Laux, Thomas, Benková, Eva, Berleth, Thomas, Zazímalová, E., Friml, Jirí, Hejato, J., Benfey, Philip, Juergens, G., Lindsey, Keith, Benfey, Philip, Benková, E., Weijers, Dolf, Grebe, Markus,, Weijers, Dolf, Jürgens, G., Benková, Eva, Heisler, Marcus, Offringa, R., Scheres, Ben, Hejátko, J., Offringa, Remko, Swarup, R., Heisler, M., Benfey, P.N.   +66 more
core   +1 more source

Characterization of the RhoGAP proteins RGA-3 and RGA-4 and the centrosomal protein SAS-5 in the early "Caenorhabditis elegans" embryo [PDF]

, 2007
The Caenorhabditis elegans embryo serves as a great tool to study cell biological processes like polarization and cell divison. The first cell division is unequal and cell polarization is dependant on the Rho GTPase regulated rearrangement of the cell ...
Schmutz, Cornelia
core   +1 more source

Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion

Cellular and Molecular Life Sciences
Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive ...
Klaus Ebnet, Michel Aurrand-Lions
doaj   +1 more source

Applying mechanical forces on Drosophila tissues in vivo using the StretchCo, a 3D-printable device

STAR Protocols
Summary: Applying mechanical forces to tissues helps to understand morphogenesis and homeostasis. Additionally, recording the dynamics of living tissues under mechanical constraints is needed to explore tissue biomechanics. Here, we present a protocol to
Mélanie Gracia, Bénédicte M. Lefèvre, Raquel Güell Alonso, Victoire Cachoux, Maria Balakireva, Boris Guirao, Damien Cuvelier, Allison J. Bardin, Yohanns Bellaïche   +8 more
doaj   +1 more source

Planar cell polarity signaling coordinates oriented cell division and cell rearrangement in clonally expanding growth plate cartilage

eLife, 2017
Both oriented cell divisions and cell rearrangements are critical for proper embryogenesis and organogenesis. However, little is known about how these two cellular events are integrated.
Yuwei Li, Ang Li, Jason Junge, Marianne Bronner   +3 more
doaj   +1 more source