Results 111 to 120 of about 433,759 (305)

Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension

Nature Communications
Convergent extension (CE) is a universal morphogenetic engine that promotes polarized tissue extension. In vertebrates, CE is regulated by non-canonical Wnt ligands signaling through “core” proteins of the planar cell polarity (PCP) pathway, including ...
Allyson Angermeier, Deli Yu, Yali Huang, Sylvie Marchetto, Jean-Paul Borg, Chenbei Chang, Jianbo Wang   +6 more
doaj   +1 more source

aPKC: the Kinase that Phosphorylates Cell Polarity [version 1; referees: 2 approved]

F1000Research, 2018
Establishing and maintaining cell polarity are dynamic processes that necessitate complicated but highly regulated protein interactions. Phosphorylation is a powerful mechanism for cells to control the function and subcellular localization of a target ...
Yang Hong
doaj   +1 more source

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. [PDF]

, 2012
Migrating cells acquire front-rear polarity with a leading edge and a trailing tail for directional movement. The Rac exchange factor Tiam1 participates in polarized cell migration with the PAR complex of PAR3, PAR6, and atypical protein kinase C ...
Collard, John G, Ginsberg, Mark H, Kaibuchi, Kozo, Kakeno, Mai, Katsumi, Akira, Kimura, Kazushi, Matsui, Toshinori, Matsuzawa, Kenji, Mizoguchi, Akira, Murase, Kiyoko, Sato, Kazuhide, Sugiyama, Ikuko, Wang, Shujie, Watanabe, Takashi, Ye, Feng   +14 more
core  

Polarizing intestinal epithelial cells electrically through Ror2 [PDF]

, 2014
© 2014.
Cao, Lin, Clevers, Hans, McCaig, Colin D, Milne, Gillian, Pu, Jin, Scott, Roderick H, Zhao, Min, Zhao, Siwei   +7 more
core   +3 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Planar cell polarity signaling coordinates oriented cell division and cell rearrangement in clonally expanding growth plate cartilage

eLife, 2017
Both oriented cell divisions and cell rearrangements are critical for proper embryogenesis and organogenesis. However, little is known about how these two cellular events are integrated.
Yuwei Li, Ang Li, Jason Junge, Marianne Bronner   +3 more
doaj   +1 more source

Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells [PDF]

, 2005
Udgivelsesdato: 2005-OctCdc42 is a small GTPase involved in the regulation of the cytoskeleton and cell polarity. To test whether Cdc42 has an essential role in the formation of filopodia or directed cell migration, we generated Cdc42-deficient ...
BRAKEBUSCH, C, CZUCHRA, A, GEFFERS, R, MEYER, H, ROTTNER, K, SCHROEDER, T, van Hengel, Jolanda, WU, XW   +7 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Protein-protein interaction network controlling establishment and maintenance of switchable cell polarity.

PLoS Genetics, 2020
Cell polarity underlies key processes in all cells, including growth, differentiation and division. In the bacterium Myxococcus xanthus, front-rear polarity is crucial for motility.
Luís António Menezes Carreira, Filipe Tostevin, Ulrich Gerland, Lotte Søgaard-Andersen   +3 more
doaj   +1 more source

Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. [PDF]

, 2019
Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein
Cheng, Hongqiang, Ghosh, Sourav, Hejran, Helen, Klezovitch, Olga, Lee, Su-Yee, Mao, Ye, Mu, Yongxin, Qin, Huaping, Scott, John, Thakar, Sonal, Vasioukhin, Valeri, Yu, Ting, Zou, Yimin   +12 more
core   +1 more source