Results 21 to 30 of about 202,026 (264)
Neural Tube Defects: From a Proteomic Standpoint
Metabolites, 2015 Neural tube defects (NTDs) are congenital birth defects classified according to their resulting morphological characteristics in newborn patients. Current diagnosis of NTDs relies largely on the structural evaluation of fetuses using ultrasound imaging ...
Tania M. Puvirajesinghe, Jean-Paul Borg
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Cell polarity and planar cell polarity (PCP) in spermatogenesis
Seminars in Cell & Developmental Biology, 2018 In adult mammalian testes, spermatids, most notably step 17-19 spermatids in stage IV-VIII tubules, are aligned with their heads pointing toward the basement membrane and their tails toward the tubule lumen. On the other hand, these polarized spermatids also align across the plane of seminiferous epithelium, mimicking planar cell polarity (PCP) found ...
Haiqi, Chen +5 more
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Cell Polarity: Getting the PARty Started [PDF]
Current Biology, 2019 Polarity establishment is a key developmental process, but what determines its timing is poorly understood. New research in Caenorhabditis elegans demonstrates that the PAR polarity system extensively reconfigures before becoming competent to polarize. By inhibiting membrane localization of anterior PAR proteins, AIR-1 (aurora A) and PLK-1 (polo kinase)
Boxem, Mike, van den Heuvel, Sander
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Biomolecules, 2019 Drosophila Schneider 2 (S2) cells are a simple and powerful system commonly used in cell biology because they are well suited for high resolution microscopy and RNAi-mediated depletion.
Mariana Osswald +2 more
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Cell Polarity: Centrosomes Release Signals for Polarization [PDF]
Current Biology, 2012 New findings reveal that, in Caenorhabditis elegans embryos, the centrosome provides signals that induce cell polarization, independently of its function as the microtubule-organizing center.
Sumiyoshi, Eisuke, Sugimoto, Asako
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Frontiers in Microbiology, 2022 The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains, which is identical to the PBM of SARS-CoV.
Yanlei Zhu +9 more
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aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
Nature Communications, 2018 The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both ...
Meghan Riddell +21 more
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Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection
Cells, 2018 Junctional adhesion molecules (JAMs) are cell surface adhesion receptors of the immunoglobulin superfamily. JAMs are involved in a variety of biological processes both in the adult organism but also during development.
Daniel Kummer, Klaus Ebnet
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Nature Communications, 2016 Defects in non-canonical Wnt/planar cell polarity signalling have recently been linked to breast cancer aggressiveness. Puvirajesinghe et al. identify VANGL2, p62/SQSTM1 and JNK as important players in this pathway which may be amenable to therapeutic ...
Tania M. Puvirajesinghe +21 more
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Coronaviruses in Polarized Epithelial Cells [PDF]
, 1995 Coronaviruses have a marked tropism for epithelial cells. In this paper the interactions of the porcine transmissible gastroenteritis virus (TGEV) and mouse hepatitis virus (MHV-A59) with epithelial cells are compared. Porcine (LLC-PK1) and murine (mTAL) epithelial cells were grown on permeable supports.
Horzinek, M.C. +6 more
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