Results 21 to 30 of about 220,716 (312)
Spectrin binding motifs regulate Scribble cortical dynamics and polarity function
eLife, 2015 The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood.
Batiste Boëda +1 more
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Cell polarity: Fixing cell polarity with Pins [PDF]
Current Biology, 2000 A protein complex is assembled in a step-wise manner at the apical pole of Drosophila neuroblasts. This complex organizes the apical-basal polarity of asymmetrically dividing neuroblasts, and may act via G-protein signalling.
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, 2023 Immune cells are responsible for pathogen detection and elimination, as well as for signaling to other cells the presence of potential danger. In order to mount an efficient immune response, they need to move and search for a pathogen, interact with other cells, and diversify the population by asymmetric cell division.
Pineau, Judith +3 more
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, 2022 Cancer is a health threat worldwide, and it is urgent to develop more sensitive cancer detection methods. Herein, a polarity-sensitive cell membrane probe (named COP) was developed for detecting cancer cells and tumors sensitively and selectively at the ...
Jiaxin Hong (6939563) +4 more
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Neural Tube Defects: From a Proteomic Standpoint
Metabolites, 2015 Neural tube defects (NTDs) are congenital birth defects classified according to their resulting morphological characteristics in newborn patients. Current diagnosis of NTDs relies largely on the structural evaluation of fetuses using ultrasound imaging ...
Tania M. Puvirajesinghe, Jean-Paul Borg
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Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]
, 2011 The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
Haastert, Peter J.M. van, +26 more
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Cell Polarity: Getting the PARty Started [PDF]
Current Biology, 2019 Polarity establishment is a key developmental process, but what determines its timing is poorly understood. New research in Caenorhabditis elegans demonstrates that the PAR polarity system extensively reconfigures before becoming competent to polarize. By inhibiting membrane localization of anterior PAR proteins, AIR-1 (aurora A) and PLK-1 (polo kinase)
Boxem, Mike, van den Heuvel, Sander
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Biomolecules, 2019 Drosophila Schneider 2 (S2) cells are a simple and powerful system commonly used in cell biology because they are well suited for high resolution microscopy and RNAi-mediated depletion.
Mariana Osswald +2 more
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Cell Polarity: Centrosomes Release Signals for Polarization [PDF]
Current Biology, 2012 New findings reveal that, in Caenorhabditis elegans embryos, the centrosome provides signals that induce cell polarization, independently of its function as the microtubule-organizing center.
Sumiyoshi, Eisuke, Sugimoto, Asako
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The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]
, 2008 © 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Sakwa, I, Höfken, T, Just, U, Tiedje, C
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