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Fly, 2011 Scientists like to consider themselves as especially objective, but, however hard we try we cannot be very different from everyone else. Like them we helplessly absorb our knowledge, our perspectives, our valuation of whether something is exciting or boring from those around us.
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Modeling the control of planar cell polarity [PDF]
WIREs Systems Biology and Medicine, 2011 AbstractA growing list of medically important developmental defects and disease mechanisms can be traced to disruption of the planar cell polarity (PCP) pathway. The PCP system polarizes cells in epithelial sheets along an axis orthogonal to their apical–basal axis.
Jeffrey D, Axelrod, Claire J, Tomlin
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Cell Polarity and Morphogenesis: Functions and Mechanisms of Cell Divisions in Vertebrate Gastrulation [PDF]
, 2004 Gastrulation shapes a vertebrate embryo from an egg-shaped aggregate of cells. In many vertebrates, massive cell divisions occur during gastrulation. In this thesis, I investigate the pattern, function, and regulation of mitotic divisions in zebrafish ...
Gong, Ying, Ying Gong
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Planar Cell Polarity and the Kidney [PDF]
Journal of the American Society of Nephrology, 2009 Planar cell polarity (PCP) is a form of spatial organization in tissue that was first described in Drosophila melanogaster. PCP plays a critical conserved role in several aspects of mammalian development. Exciting data implicate PCP in normal kidney development and suggest the loss of oriented cell division and convergent extension downstream of ...
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Planar Polarity: Forcing Cells Into Line [PDF]
Current Biology, 2015 Polarisation of tissues in the plane of an epithelium is fundamental for both animal morphogenesis and organ function. A new paper describes a role for mechanical cues in determining how such polarity is aligned with the body axes.
Strutt, Helen, Strutt, David
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Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions
iScience, 2020 Summary: Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Jason Ear +6 more
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CPLANE Complex and Ciliopathies
Biomolecules, 2022 Primary cilia are non-motile organelles associated with the cell cycle, which can be found in most vertebrate cell types. Cilia formation occurs through a process called ciliogenesis, which involves several mechanisms including planar cell polarity (PCP)
Jesús Eduardo Martín-Salazar +1 more
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Methods for studying planar cell polarity [PDF]
Methods, 2014 Planar cell polarity (PCP) is the polarity of epithelial cells in the plane orthogonal to the apical-basal axis, and is controlled by a partially defined signaling system. PCP related signaling also plays roles in cell migration, tissue re-organization and stem cell differentiation during embryonic development, and later, in regeneration and repair ...
Jessica, Olofsson, Jeffrey D, Axelrod
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Frontiers in Cell and Developmental Biology, 2019 Formation of the anteroposterior and dorsoventral body axis in Caenorhabditis elegans depends on cortical flows and advection of polarity determinants. The role of this patterning mechanism in tissue polarization after formation of cell-cell contacts is ...
Priyanka Dutta +2 more
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Afferent neurons of the zebrafish lateral line are strict selectors of hair-cell orientation. [PDF]
PLoS ONE, 2009 Hair cells in the inner ear display a characteristic polarization of their apical stereocilia across the plane of the sensory epithelium. This planar orientation allows coherent transduction of mechanical stimuli because the axis of morphological ...
Adèle Faucherre +3 more
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