Nature Communications, 2022 Planar cell polarity (PCP) is critical for tissue-wide coordination and successful development. Here Jussila et al. generate a GFP-Vangl2 fusion for live imaging and discover a surprising directionality to the intercellular propagation of cell polarity ...
Maria Jussila +4 more
doaj +1 more source
The distribution of Dishevelled in convergently extending mesoderm [PDF]
, 2013 Convergent extension (CE) is a conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity (PCP) pathway.
Bretschneider, Till +3 more
core +1 more source
Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division
eLife, 2017 Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g.
Jennifer J Banerjee +5 more
doaj +1 more source
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice [PDF]
, 2018 Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is ...
A Kamalakar +66 more
core +3 more sources
Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling
Journal of Cell Biology, 2020 The planar cell polarity (PCP) pathway is essential for tissue morphogenesis. However, the roles of Wnt ligands in the mammalian PCP pathway remain poorly understood.
André Landin Malt +4 more
semanticscholar +1 more source
Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity [PDF]
Developmental Cell, 2011 Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic ...
Gray, Ryan S. +2 more
openaire +2 more sources
Planar cell polarity signaling guides cochlear innervation. [PDF]
Dev Biol, 2022 Deans MR.
europepmc +3 more sources
Modelling and Analysis of Planar Cell Polarity [PDF]
Bulletin of Mathematical Biology, 2009 Planar cell polarity (PCP) occurs in the epithelia of many animals and can lead to the alignment of hairs, bristles, and feathers. Here, we present two approaches to modelling this phenomenon. The aim is to discover the basic mechanisms that drive PCP, while keeping the models mathematically tractable.
Schamberg, Sabine +3 more
openaire +4 more sources
Interferometric method for determining the sum of the flexoelectric coefficients (e1+e3) in an ionic nematic material [PDF]
, 2008 The time-dependent periodic distortion profile in a nematic liquid crystal phase grating has been measured from the displacement of tilt fringes in a Mach-Zehnder interferometer.
A. A. T. Smith +5 more
core +1 more source
A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. [PDF]
, 2020 Alveolar formation increases the surface area for gas-exchange and is key to the physiological function of the lung. Alveolar epithelial cells, myofibroblasts and endothelial cells undergo coordinated morphogenesis to generate epithelial folds (secondary
Chou, Yu-Ting +7 more
core +1 more source