Results 51 to 60 of about 150,481 (338)

Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity

Development, 2020
Planar cell polarity (PCP) is essential for tissue morphogenesis and homeostasis; however, the mechanisms that orchestrate the cell shape and packing dynamics required to establish PCP are poorly understood.
Krishnanand Padmanabhan, Hanna Grobe, Jonathan Cohen, Arad Soffer, Adnan Mahly, O. Adir, R. Zaidel-Bar, Chen Luxenburg   +7 more
semanticscholar   +1 more source

The cell biology of planar cell polarity [PDF]

Journal of Cell Biology, 2014
Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells.
openaire   +2 more sources

A Dual Function for Prickle in Regulating Frizzled Stability during Feedback-Dependent Amplification of Planar Polarity [PDF]

, 2017
The core planar polarity pathway coordinates epithelial cell polarity during animal development, and loss of its activity gives rise to a range of defects, from aberrant morphogenetic cell movements to failure to correctly orient structures, such as ...
Abley, Adler, Aigouy, Amonlirdviman, Aw, Bastock, Burak, Chau, Chen, Cho, Clague, Davey, David Strutt, Feiguin, Goodrich, Gubb, Gubb, Hale, Helen Strutt, Hoeller, Howell, Hunter, Jenny, Jenny, Johnson, Katherine H. Fisher, Klein, Koshland, Lawrence, Le Garrec, Levayer, Marois, Matsubara, Maung, McGuire, Narimatsu, Perrimon, Rawls, Samantha J. Warrington, Schamberg, Snapp, Struhl, Strutt, Strutt, Strutt, Strutt, Strutt, Strutt, Strutt, Strutt, Strutt, Strutt, Taylor, Tree, Usui, van der Bliek, Vinson, Wolff, Wu   +58 more
core   +1 more source

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

Nature Communications, 2020
The number of patients diagnosed with chronic bile duct disease is increasing and in most cases these diseases result in chronic ductular scarring, necessitating liver transplantation.
David H. Wilson, E. Jarman, R. Mellin, M. Wilson, S. Waddell, P. Tsokkou, N. Younger, A. Raven, S. R. Bhalla, A. T. Noll, S. Damink, S. Damink, F. Schaap, F. Schaap, Ping Chen, D. O. Bates, D. O. Bates, J. M. Banales, C. Dean, D. Henderson, O. Sansom, T. Kendall, L. Boulter   +22 more
semanticscholar   +1 more source

Planar Polarity: Forcing Cells Into Line [PDF]

Current Biology, 2015
Polarisation of tissues in the plane of an epithelium is fundamental for both animal morphogenesis and organ function. A new paper describes a role for mechanical cues in determining how such polarity is aligned with the body axes.
Strutt, Helen, Strutt, David
openaire   +2 more sources

Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP

G3: Genes, Genomes, Genetics, 2017
The Planar cell Polarity Effector (PPE) genes inturned, fuzzy, and fritz are downstream components in the frizzled/starry night signaling pathway, and their function is instructed by upstream Planar Cell Polarity (PCP) core genes such as frizzled and ...
Ying Wang, Victor F. Naturale, Paul N. Adler   +2 more
doaj   +1 more source

Expression of avian prickle genes during early development and organogenesis [PDF]

, 2008
Chicken homologues of prickle-1 (pk-1) and prickle-2 (pk-2) were isolated to gain insight into the extent of planar cell polarity signaling during avian embryogenesis.
Carreira-Barbosa, Chan, Classen, Cooper, Crompton, Dawid, Deans, Desnoyers, Drusco, Fanto, Formstone, Fraser, Gibson, Gros, Gubb, Hamburger, Jiang, Jones, Kadrmas, Katoh, Lawrence, Lecuit, Maurer-Stroh, Michelsen, Münsterberg, Porter, Rath, Schmidt, Seifert, Shimada, Shimojo, Shimojo, Slusarski, Smith, Somerville, Sproul, Strutt, Tsuda, Veeman, Xue, Zhou   +40 more
core   +1 more source

Planar cell polarity signaling in the development of left-right asymmetry.

Current Opinion in Cell Biology, 2020
The planar cell polarity (PCP) signaling pathway, principally understood from work in Drosophila, is now known to contribute to development in a broad swath of the animal kingdom, and its impairment leads to developmental malformations and diseases ...
J. Axelrod
semanticscholar   +1 more source

Methods for studying planar cell polarity [PDF]

Methods, 2014
Planar cell polarity (PCP) is the polarity of epithelial cells in the plane orthogonal to the apical-basal axis, and is controlled by a partially defined signaling system. PCP related signaling also plays roles in cell migration, tissue re-organization and stem cell differentiation during embryonic development, and later, in regeneration and repair ...
Jessica, Olofsson, Jeffrey D, Axelrod
openaire   +2 more sources

Prickle1 is required for EMT and migration of zebrafish cranial neural crest [PDF]

, 2019
The neural crest—a key innovation of the vertebrates—gives rise to diverse cell types including melanocytes, neurons and glia of the peripheral nervous system, and chondrocytes of the jaw and skull.
Ahsan, Kamil, Huang, Christina, Prince, Victoria E., Rocha, Manuel, Singh, Noor   +4 more
core   +1 more source