Results 71 to 80 of about 150,481 (338)
Update on the Role of the Non-Canonical Wnt/Planar Cell Polarity Pathway in Neural Tube Defects
Cells, 2019 Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most severe and common malformations of the central nervous system affecting 0.7–3 per 1000 live births.
Mingqin Wang +3 more
semanticscholar +1 more source
Planar Cell Polarity and the Kidney [PDF]
Journal of the American Society of Nephrology, 2009 Planar cell polarity (PCP) is a form of spatial organization in tissue that was first described in Drosophila melanogaster. PCP plays a critical conserved role in several aspects of mammalian development. Exciting data implicate PCP in normal kidney development and suggest the loss of oriented cell division and convergent extension downstream of ...
openaire +2 more sources
Planar Cell Polarity Signaling: The Developing Cell's Compass [PDF]
Cold Spring Harbor Perspectives in Biology, 2009 Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream ...
Eszter K, Vladar +2 more
openaire +2 more sources
Functional modelling of planar cell polarity: an approach for identifying molecular function. [PDF]
, 2013 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Hancock, John M, Hazelwood, Lee D
core +3 more sources
The Kidney and Planar Cell Polarity [PDF]
, 2012 Planar cell polarity (PCP) or tissue polarity describes a coordinated polarity at the plane of the tissue where most or all cells within a tissue are polarized in one direction. It is perpendicular to the apical-basal polarity of the cell. PCP is manifested readily in the Drosophila wing and cuticle bristles, Drosophila eye ommatidia, and mammalian ...
Thomas J, Carroll, Jing, Yu
openaire +2 more sources
Biology Open, 2015 The vertebrate neural tube forms as a result of complex morphogenetic movements, which require the functions of several core planar cell polarity (PCP) proteins, including Vangl2 and Prickle.
Olga Ossipova +2 more
doaj +1 more source
Out-of-surface vortices in spherical shells [PDF]
, 2012 The interplay of topological defects with curvature is studied for out-of-surface magnetic vortices in thin spherical nanoshells. In the case of easy-surface Heisenberg magnet it is shown that the curvature of the underlying surface leads to a coupling ...
A. Hubert +9 more
core +3 more sources
Frontiers in Genetics, 2019 Proper ciliary basal body positioning within a cell is key for cilia functioning. Centriole and basal body positioning depends on signaling pathways such as the planar cell polarity pathway (PCP) governed by Frizzled (Fz-PCP).
Sergio Garrido-Jimenez +2 more
doaj +1 more source
Afadin orients cell division to position the tubule lumen in developing renal tubules [PDF]
, 2017 In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found the F-actin binding protein Afadin is required for lumen continuity in developing renal ...
Brakeman, Paul R. +9 more
core +2 more sources
Nature Communications, 2017 It is unclear if there is an interaction between apical-basal (AB) polarity and planar cell polarity (PCP) pathways during morphogenesis. Here, the authors define a role for the melanoma cell adhesion molecule (MCAM), known to regulate PCP, in AB ...
Qian Gao +11 more
doaj +1 more source