Results 91 to 100 of about 150,481 (338)
DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila.
PLoS Genetics, 2020 The core planar polarity proteins are essential mediators of tissue morphogenesis, controlling both the polarised production of cellular structures and polarised tissue movements.
Helen Strutt, David Strutt
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Actomyosin-based Self-organization of cell internalization during C. elegans gastrulation [PDF]
, 2012 Background: Gastrulation is a key transition in embryogenesis; it requires self-organized cellular coordination, which has to be both robust to allow efficient development and plastic to provide adaptability. Despite the conservation of gastrulation as a
Bao, Zhirong +4 more
core +2 more sources
Ubiquitin Connects with Planar Cell Polarity [PDF]
Cell, 2009 Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.
openaire +2 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. [PDF]
, 2020 Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited.
Bernstein, Daniel +25 more
core
Biophysics and Physicobiology, 2019 Organs and tissues in multi-cellular organisms exhibit various morphologies. Tubular organs have multi-scale morphological features which are closely related to their functions. Here we discuss morphogenesis and the mechanical functions of the vertebrate
H. Koyama, Dongbo Shi, T. Fujimori
semanticscholar +1 more source
Planar cell polarity (PCP) proteins and spermatogenesis [PDF]
Seminars in Cell & Developmental Biology, 2016 In adult mammalian testes, spermatogenesis is comprised of several discrete cellular events that work in tandem to support the transformation and differentiation of diploid spermatogonia to haploid spermatids in the seminiferous epithelium during the seminiferous epithelial cycle. These include: self-renewal of spermatogonial stem cells via mitosis and
Haiqi, Chen, C Yan, Cheng
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Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials
Advanced Engineering Materials, EarlyView.Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai +2 more
wiley +1 more source
Reciprocal and dynamic polarization of planar cell polarity core components and myosin
eLife, 2015 The Ciona notochord displays planar cell polarity (PCP), with anterior localization of Prickle (Pk) and Strabismus (Stbm). We report that a myosin is polarized anteriorly in these cells and strongly colocalizes with Stbm.
Erin Newman-Smith +4 more
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Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants
Acta Neuropathologica Communications, 2021 The prevalence of congenital hydrocephalus has been estimated at 1.1 per 1000 infants when including cases diagnosed before 1 year of age after exclusion of neural tube defects. Classification criteria are based either on CSF dynamics, pathophysiological
Florent Marguet +10 more
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