How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? [PDF]
Open Biology, 2021 Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway.
Helen Strutt, David Strutt
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Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function [PDF]
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development [PDF]
eLifeIn developing epithelia, cells become planar polarised through asymmetric localisation of the core planar polarity proteins to opposite cell membranes, where they form stable intercellular complexes.
Alexandre Carayon +2 more
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Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing [PDF]
Nature CommunicationsPlanar polarity establishment in epithelia requires interpretation of directional tissue-level information at cellular and molecular levels. Mechanical forces exerted during tissue morphogenesis are emerging as crucial tissue-level directional cues, yet ...
Su Ee Tan, David Strutt
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Rapid Disruption of Dishevelled Activity Uncovers an Intercellular Role in Maintenance of Prickle in Core Planar Polarity Protein Complexes [PDF]
Cell Reports, 2018 Summary: Planar polarity, the coordinated polarization of cells in the plane of a tissue, is important for normal tissue development and function. Proteins of the core planar polarity pathway become asymmetrically localized at the junctions between cells
Margarida Ressurreição +2 more
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DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila. [PDF]
PLoS Genetics, 2020 The core planar polarity proteins are essential mediators of tissue morphogenesis, controlling both the polarised production of cellular structures and polarised tissue movements.
Helen Strutt, David Strutt
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Centriole Translational Planar Polarity in Monociliated Epithelia [PDF]
CellsCiliated epithelia are widespread in animals and play crucial roles in many developmental and physiological processes. Epithelia composed of multi-ciliated cells allow for directional fluid flow in the trachea, oviduct and brain cavities.
Antoine Donati +2 more
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Planar cell polarity of the kidney [PDF]
Experimental Cell Research, 2016 Planar cell polarity (PCP) or tissue polarity refers to the polarization of tissues perpendicular to the apical-basal axis. Most epithelia, including the vertebrate kidney, show signs of planar polarity. In the kidney, defects in planar polarity are attributed to several disease states including multiple forms of cystic kidney disease.
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Planar polarity: converting a morphogen gradient into cellular polarity. [PDF]
Curr Biol, 2015 Epithelial cells are polarized within the apico-basal and planar axes. The latter - planar cell polarity - requires long-range regulation of orientation as well as short-range, cell-to-cell realignment through feedback loops. New insights into the long-range, gradient-type regulation reveal how a kinase translates the morphogen gradient input into ...
Collu GM, Mlodzik M.
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Membrane trafficking in morphogenesis and planar polarity. [PDF]
Traffic, 2018 Our understanding of how membrane trafficking pathways function to direct morphogenetic movements and the planar polarization of developing tissues is a new and emerging field. While a central focus of developmental biology has been on how protein asymmetries and cytoskeletal force generation direct cell shaping, the role of membrane trafficking in ...
Xie Y, Miao H, Blankenship JT.
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